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MGP000426

Record overview

MGPD IDMGP000426
Gene ID857
SpeciesHomo sapiens (Human)
Gene Namecaveolin 1, caveolae protein, 22kDa
Gene Symbol CAV1
SynonymsCGL3; PPH3; BSCL3; LCCNS; VIP21; MSTP085;
Alternate namescaveolin-1; cell growth-inhibiting protein 32;
Chromosome7
Map Location7q31.1
SummaryThe scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade. Caveolin 1 and caveolin 2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Mutations in this gene have been associated with Berardinelli-Seip congenital lipodystrophy. Alternatively spliced transcripts encode alpha and beta isoforms of caveolin 1.[provided by RefSeq, Mar 2010]
OrthologsView orthologs and multiple alignments for CAV1

Proteins

caveolin-1 isoform alpha
Refseq ID:NP_001744
Protein GI:15451856
UniProt ID:Q03135
mRNA ID:NM_001753
Length:178
RefSeq Status:
MSGGKYVDSEGHLYTVPIREQGNIYKPNNKAMADELSEKQVYDAHTKEIDLVNRDPKHLNDDVVKIDFEDVIAEPEGTHSFDGIWKASFTTFTVTKYWFY
RLLSALFGIPMALIWGIYFAILSFLHIWAVVPCIKSFLIEIQCISRVYSIYVHTVCDPLFEAVGKIFSNVRINLQKEI
 
caveolin-1 isoform beta
Refseq ID:NP_001166366
Protein GI:290542359
UniProt ID:Q2TNI1
mRNA ID:NM_001172895
Length:147
RefSeq Status:
MADELSEKQVYDAHTKEIDLVNRDPKHLNDDVVKIDFEDVIAEPEGTHSFDGIWKASFTTFTVTKYWFYRLLSALFGIPMALIWGIYFAILSFLHIWAVV
PCIKSFLIEIQCISRVYSIYVHTVCDPLFEAVGKIFSNVRINLQKEI
 
caveolin-1 isoform beta
Refseq ID:NP_001166367
Protein GI:290542361
UniProt ID:Q2TNI1
mRNA ID:NM_001172896
Length:147
RefSeq Status:
Protein sequence is identical to GI:290542359 (mRNA isoform)
 
caveolin-1 isoform beta
Refseq ID:NP_001166368
Protein GI:290542363
UniProt ID:Q2TNI1
mRNA ID:NM_001172897
Length:147
RefSeq Status:
Protein sequence is identical to GI:290542359 (mRNA isoform)
 
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