MGP Database

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MGP000426

Ontology/Pathway Information

Entrez Gene ID857
Gene Namecaveolin 1, caveolae protein, 22kDa
Gene Symbol CAV1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0002080 IEA:EnsemblCacrosomal membrane
GO:0016324 IDA:BHF-UCLCapical plasma membrane
GO:0016323 IDA:BHF-UCLCbasolateral plasma membrane
GO:0005901 IDA:UniProtKBCcaveola
GO:0005938 IEA:EnsemblCcell cortex
GO:0005929 IEA:EnsemblCcilium
GO:0031410 IDA:UniProtKBCcytoplasmic vesicle
GO:0030666 TAS:ReactomeCendocytic vesicle membrane
GO:0005783 IDA:HGNCCendoplasmic reticulum
GO:0005768 IDA:UniProtKBCendosome
GO:0005925 IDA:UniProtKBCfocal adhesion
GO:0000139 IDA:HGNCCGolgi membrane
GO:0005887 IEA:EnsemblCintegral component of plasma membrane
GO:0005622 IDA:BHF-UCLCintracellular
GO:0005811 TAS:ReactomeClipid particle
GO:0045121 IDA:UniProtKBCmembrane raft
GO:0048471 IDA:UniProtKBCperinuclear region of cytoplasm
GO:0005886 IDA:UniProtKBCplasma membrane
GO:0043234 IDA:MGICprotein complex
GO:0015485 TAS:HGNCFcholesterol binding
GO:0019899 IPI:UniProtKBFenzyme binding
GO:0042802 IPI:BHF-UCLFidentical protein binding
GO:0070320 IDA:BHF-UCLFinward rectifier potassium channel inhibitor activity
GO:0044325 IPI:BHF-UCLFion channel binding
GO:0050998 IPI:BHF-UCLFnitric-oxide synthase binding
GO:0005113 NAS:BHF-UCLFpatched binding
GO:0016504 ISS:BHF-UCLFpeptidase activator activity
GO:0032947 TAS:BHF-UCLFprotein complex scaffold
GO:0019901 IPI:BHF-UCLFprotein kinase binding
GO:0005102 IPI:BHF-UCLFreceptor binding
GO:0005198 IDA:UniProtKBFstructural molecule activity
GO:0001525 IEA:EnsemblPangiogenesis
GO:0097190 IMP:UniProtKBPapoptotic signaling pathway
GO:0007596 TAS:ReactomePblood coagulation
GO:0055074 ISS:BHF-UCLPcalcium ion homeostasis
GO:0006816 ISS:BHF-UCLPcalcium ion transport
GO:0070836 IMP:BHF-UCLPcaveola assembly
GO:0072584 IDA:UniProtKBPcaveolin-mediated endocytosis
GO:0006874 ISS:BHF-UCLPcellular calcium ion homeostasis
GO:0071455 IMP:UniProtKBPcellular response to hyperoxia
GO:0009267 IEP:BHF-UCLPcellular response to starvation
GO:0042632 ISS:BHF-UCLPcholesterol homeostasis
GO:0030301 TAS:HGNCPcholesterol transport
GO:0051480 IDA:BHF-UCLPcytosolic calcium ion homeostasis
GO:0000188 ISS:BHF-UCLPinactivation of MAPK activity
GO:0007595 IEA:EnsemblPlactation
GO:0050900 TAS:ReactomePleukocyte migration
GO:0019915 ISS:BHF-UCLPlipid storage
GO:0032507 ISS:BHF-UCLPmaintenance of protein location in cell
GO:0030879 ISS:BHF-UCLPmammary gland development
GO:0060056 ISS:BHF-UCLPmammary gland involution
GO:0000165 IEA:EnsemblPMAPK cascade
GO:0051899 ISS:BHF-UCLPmembrane depolarization
GO:2000811 IMP:UniProtKBPnegative regulation of anoikis
GO:0030514 IDA:BHF-UCLPnegative regulation of BMP signaling pathway
GO:0090090 ISS:UniProtKBPnegative regulation of canonical Wnt signaling pathway
GO:0001960 IEA:EnsemblPnegative regulation of cytokine-mediated signaling pathway
GO:0001937 ISS:BHF-UCLPnegative regulation of endothelial cell proliferation
GO:0030857 ISS:BHF-UCLPnegative regulation of epithelial cell differentiation
GO:0046426 ISS:BHF-UCLPnegative regulation of JAK-STAT cascade
GO:0043409 ISS:BHF-UCLPnegative regulation of MAPK cascade
GO:0045019 ISS:BHF-UCLPnegative regulation of nitric oxide biosynthetic process
GO:0051001 IEA:EnsemblPnegative regulation of nitric-oxide synthase activity
GO:0033137 IDA:BHF-UCLPnegative regulation of peptidyl-serine phosphorylation
GO:1900085 IMP:BHF-UCLPnegative regulation of peptidyl-tyrosine autophosphorylation
GO:0048550 IMP:UniProtKBPnegative regulation of pinocytosis
GO:1901380 IMP:BHF-UCLPnegative regulation of potassium ion transmembrane transport
GO:0032091 IDA:BHF-UCLPnegative regulation of protein binding
GO:0061099 IMP:BHF-UCLPnegative regulation of protein tyrosine kinase activity
GO:0031397 IMP:UniProtKBPnegative regulation of protein ubiquitination
GO:0000122 ISS:UniProtKBPnegative regulation of transcription from RNA polymerase II promoter
GO:0042524 IEA:EnsemblPnegative regulation of tyrosine phosphorylation of Stat5 protein
GO:0033484 ISS:BHF-UCLPnitric oxide homeostasis
GO:0046209 TAS:ReactomePnitric oxide metabolic process
GO:0010524 ISS:BHF-UCLPpositive regulation of calcium ion transport into cytosol
GO:0090263 IMP:BHF-UCLPpositive regulation of canonical Wnt signaling pathway
GO:2001238 IMP:UniProtKBPpositive regulation of extrinsic apoptotic signaling pathway
GO:2001244 IMP:UniProtKBPpositive regulation of intrinsic apoptotic signaling pathway
GO:0048554 ISS:BHF-UCLPpositive regulation of metalloenzyme activity
GO:0033138 IDA:BHF-UCLPpositive regulation of peptidyl-serine phosphorylation
GO:0045907 ISS:BHF-UCLPpositive regulation of vasoconstriction
GO:0051260 ISS:BHF-UCLPprotein homooligomerization
GO:0008104 ISS:BHF-UCLPprotein localization
GO:2000286 IMP:BHF-UCLPreceptor internalization involved in canonical Wnt signaling pathway
GO:0030193 IMP:BHF-UCLPregulation of blood coagulation
GO:0098909 IC:BHF-UCLPregulation of cardiac muscle cell action potential involved in regulation of contraction
GO:0019217 ISS:BHF-UCLPregulation of fatty acid metabolic process
GO:1901979 IMP:BHF-UCLPregulation of inward rectifier potassium channel activity
GO:0098903 IMP:BHF-UCLPregulation of membrane repolarization during action potential
GO:0050999 TAS:ReactomePregulation of nitric-oxide synthase activity
GO:0052547 ISS:BHF-UCLPregulation of peptidase activity
GO:0006940 ISS:BHF-UCLPregulation of smooth muscle contraction
GO:0003057 IEA:EnsemblPregulation of the force of heart contraction by chemical signal
GO:0051592 ISS:BHF-UCLPresponse to calcium ion
GO:0043627 IDA:MGIPresponse to estrogen
GO:0001666 ISS:BHF-UCLPresponse to hypoxia
GO:0002931 IEA:EnsemblPresponse to ischemia
GO:0032570 IDA:MGIPresponse to progesterone
GO:0007519 ISS:BHF-UCLPskeletal muscle tissue development
GO:0044281 TAS:ReactomePsmall molecule metabolic process
GO:0031295 IDA:UniProtKBPT cell costimulation
GO:0006641 ISS:BHF-UCLPtriglyceride metabolic process
GO:0001570 ISS:BHF-UCLPvasculogenesis
GO:0042310 IEA:EnsemblPvasoconstriction
GO:0016050 IDA:BHF-UCLPvesicle organization
GO:0016032 IEA:UniProtKB-KWPviral process
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_12560Basigin interactions
REACT_12051Cell surface interactions at the vascular wall
REACT_264034disassembly of the destruction complex and recruitment of AXIN to the membrane
REACT_116125Disease
REACT_12477eNOS activation
REACT_12389eNOS activation and regulation
REACT_604Hemostasis
REACT_494Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
REACT_602Lipid digestion, mobilization, and transport
REACT_111217Metabolism
REACT_22258Metabolism of lipids and lipoproteins
REACT_12508Metabolism of nitric oxide
REACT_264594misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
REACT_12541NOSTRIN mediated eNOS trafficking
REACT_264378RNF mutants show enhanced WNT signaling and proliferation
REACT_12529Signaling by VEGF
REACT_11045Signaling by Wnt
REACT_264125Signaling by WNT in cancer
REACT_111102Signal Transduction
REACT_264596TCF dependent signaling in response to WNT
REACT_264464VEGFA-VEGFR2 Pathway
REACT_263991VEGFR2 mediated vascular permeability
REACT_264356XAV939 inhibits tankyrase, stabilizing AXIN
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