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MGP000432

UniProt Annotations

Entry Information
Gene Namecarbonyl reductase 3
Protein EntryCBR3_HUMAN
UniProt IDO75828
SpeciesHuman
Comments
Comment typeDescription
Biophysicochemical PropertiesKinetic parameters: KM=25 uM for menadione {ECO:0000269|PubMed:15537833, ECO:0000269|PubMed:18493841}; KM=43 uM for menadione {ECO:0000269|PubMed:15537833, ECO:0000269|PubMed:18493841}; KM=90 uM for NADPH {ECO:0000269|PubMed:15537833, ECO:0000269|PubMed:18493841}; KM=38 uM for NADPH {ECO:0000269|PubMed:15537833, ECO:0000269|PubMed:18493841}; pH dependence: Optimum pH is 5.5-7. {ECO:0000269|PubMed:15537833, ECO:0000269|PubMed:18493841};
Catalytic ActivityR-CHOH-R' + NADP(+) = R-CO-R' + NADPH.
FunctionHas low NADPH-dependent oxidoreductase activity towards 4-benzoylpyridine and menadione (in vitro). {ECO:0000269|PubMed:18493841}.
SimilarityBelongs to the short-chain dehydrogenases/reductases (SDR) family. {ECO:0000305}.
Subcellular LocationCytoplasm {ECO:0000269|PubMed:18493841}.
Tissue SpecificityDetected in ovary, pancreas, intestine, colon, kidney, brain, thymus, lung, heart, liver, spleen, leukocyte, prostate and testis. {ECO:0000269|PubMed:18493841}.
Web ResourceName=SeattleSNPs; URL="http://pga.gs.washington.edu/data/cbr3/";
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