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MGP000434

Record overview

MGPD IDMGP000434
Gene ID883
SpeciesHomo sapiens (Human)
Gene Namecysteine conjugate-beta lyase, cytoplasmic
Gene Symbol CCBL1
SynonymsGTK; KAT1; KATI;
Alternate nameskynurenine--oxoglutarate transaminase 1; beta-lysase, kidney; glutamine transaminase K; kyneurenine aminotransferase; kynurenine aminotransferase I; cysteine-S-conjugate beta-lyase; glutamine--phenylpyruvate transaminase; kynurenine--oxoglutarate transaminase I; glutamine-phenylpyruvate aminotransferase; cysteine conjugate-beta lyase; cytoplasmic (glutamine transaminase K, kyneurenine aminotransferase);
Chromosome9
Map Location9q34.11
EC Number2.6.1.7
SummaryThis gene encodes a cytosolic enzyme that is responsible for the metabolism of cysteine conjugates of certain halogenated alkenes and alkanes. This metabolism can form reactive metabolites leading to nephrotoxicity and neurotoxicity. Increased levels of this enzyme have been linked to schizophrenia. Multiple transcript variants that encode different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for CCBL1

Proteins

kynurenine--oxoglutarate transaminase 1 isoform a
Refseq ID:NP_001116143
Protein GI:169881279
UniProt ID:Q16773
mRNA ID:NM_001122671
Length:422
RefSeq Status:
MAKQLQARRLDGIDYNPWVEFVKLASEHDVVNLGQGFPDFPPPDFAVEAFQHAVSGDFMLNQYTKTFGYPPLTKILASFFGELLGQEIDPLRNVLVTVGG
YGALFTAFQALVDEGDEVIIIEPFFDCYEPMTMMAGGRPVFVSLKPGPIQNGELGSSSNWQLDPMELAGKFTSRTKALVLNTPNNPLGKVFSREELELVA
SLCQQHDVVCITDEVYQWMVYDGHQHISIASLPGMWERTLTIGSAGKTFSATGWKVGWVLGPDHIMKHLRTVHQNSVFHCPTQSQAAVAESFEREQLLFR
QPSSYFVQFPQAMQRCRDHMIRSLQSVGLKPIIPQGSYFLITDISDFKRKMPDLPGAVDEPYDRRFVKWMIKNKGLVAIPVSIFYSVPHQKHFDHYIRFC
FVKDEATLQAMDEKLRKWKVEL
 
kynurenine--oxoglutarate transaminase 1 isoform a
Refseq ID:NP_004050
Protein GI:95147551
UniProt ID:Q16773
mRNA ID:NM_004059
Length:422
RefSeq Status:
Protein sequence is identical to GI:169881279 (mRNA isoform)
 
kynurenine--oxoglutarate transaminase 1 isoform b
Refseq ID:NP_001116144
Protein GI:169881281
UniProt ID:Q16773
mRNA ID:NM_001122672
Length:372
RefSeq Status:
MAKQLQARRLDGIDYNPWVEFVKLASEHDVVNLGQGFPDFPPPDFAVEAFQHAVSGDFMLNQYTKTFVIIIEPFFDCYEPMTMMAGGRPVFVSLKPGPIQ
NGELGSSSNWQLDPMELAGKFTSRTKALVLNTPNNPLGKVFSREELELVASLCQQHDVVCITDEVYQWMVYDGHQHISIASLPGMWERTLTIGSAGKTFS
ATGWKVGWVLGPDHIMKHLRTVHQNSVFHCPTQSQAAVAESFEREQLLFRQPSSYFVQFPQAMQRCRDHMIRSLQSVGLKPIIPQGSYFLITDISDFKRK
MPDLPGAVDEPYDRRFVKWMIKNKGLVAIPVSIFYSVPHQKHFDHYIRFCFVKDEATLQAMDEKLRKWKVEL
 
kynurenine--oxoglutarate transaminase 1 isoform c
Refseq ID:NP_001274319
Protein GI:565671772
UniProt ID:B7Z4W5
mRNA ID:NM_001287390
Length:516
RefSeq Status:
MFRTAAAISVHLVGPLQGRKAGAPLTWFLHQTQVAEKNVGSPAPRPTSHLGLANPQERKVPQGPQSPCEVPAAEGILRTGGAKLPIQGHPAKLAMAKQLQ
ARRLDGIDYNPWVEFVKLASEHDVVNLGQGFPDFPPPDFAVEAFQHAVSGDFMLNQYTKTFGYPPLTKILASFFGELLGQEIDPLRNVLVTVGGYGALFT
AFQALVDEGDEVIIIEPFFDCYEPMTMMAGGRPVFVSLKPGPIQNGELGSSSNWQLDPMELAGKFTSRTKALVLNTPNNPLGKVFSREELELVASLCQQH
DVVCITDEVYQWMVYDGHQHISIASLPGMWERTLTIGSAGKTFSATGWKVGWVLGPDHIMKHLRTVHQNSVFHCPTQSQAAVAESFEREQLLFRQPSSYF
VQFPQAMQRCRDHMIRSLQSVGLKPIIPQGSYFLITDISDFKRKMPDLPGAVDEPYDRRFVKWMIKNKGLVAIPVSIFYSVPHQKHFDHYIRFCFVKDEA
TLQAMDEKLRKWKVEL
 
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