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MGP000434

UniProt Annotations

Entry Information
Gene Namecysteine conjugate-beta lyase, cytoplasmic
Protein EntryKAT1_HUMAN
UniProt IDQ16773
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q16773-1; Sequence=Displayed; Name=2; IsoId=Q16773-2; Sequence=VSP_009875; Name=3; IsoId=Q16773-3; Sequence=VSP_009876, VSP_009877;
Catalytic ActivityAn L-cysteine-S-conjugate + H(2)O = RSH + NH(3) + pyruvate. {ECO:0000269|PubMed:19338303}.
Catalytic ActivityL-glutamine + phenylpyruvate = 2- oxoglutaramate + L-phenylalanine. {ECO:0000269|PubMed:19338303}.
Catalytic ActivityL-kynurenine + 2-oxoglutarate = 4-(2- aminophenyl)-2,4-dioxobutanoate + L-glutamate. {ECO:0000269|PubMed:19338303}.
CofactorName=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence={ECO:0000269|PubMed:15364907, ECO:0000269|PubMed:19338303};
Enzyme RegulationInhibited by tryptophan, indole-3-pyruvic acid, 3-indolepropionic acid, DL-indole-3-lactic acid, indole-3-acetic acid (IAC) and Tris. {ECO:0000269|PubMed:19338303}.
FunctionCatalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Metabolizes the cysteine conjugates of certain halogenated alkenes and alkanes to form reactive metabolites. Catalyzes the beta- elimination of S-conjugates and Se-conjugates of L- (seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond. {ECO:0000269|PubMed:19338303}.
PathwayAmino-acid degradation; L-kynurenine degradation; kynurenate from L-kynurenine: step 1/2.
SimilarityBelongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. {ECO:0000305}.
Subcellular LocationCytoplasm.
SubunitHomodimer. {ECO:0000269|PubMed:15364907}.
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