MGP Database

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MGP000439

Ontology/Pathway Information

Entrez Gene ID891
Gene Namecyclin B1
Gene Symbol CCNB1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005813 IDA:UniProtKBCcentrosome
GO:0000942 IDA:BHF-UCLCcondensed nuclear chromosome outer kinetochore
GO:0005737 IDA:UniProtKBCcytoplasm
GO:0005829 TAS:ReactomeCcytosol
GO:0016020 IEA:EnsemblCmembrane
GO:0005654 TAS:ReactomeCnucleoplasm
GO:0005634 IDA:BHF-UCLCnucleus
GO:0000922 IDA:BHF-UCLCspindle pole
GO:0035173 IEA:EnsemblFhistone kinase activity
GO:0005113 IPI:BHF-UCLFpatched binding
GO:0019901 IPI:UniProtKBFprotein kinase binding
GO:0031145 TAS:ReactomePanaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0071398 IEA:EnsemblPcellular response to fatty acid
GO:0071456 IEA:EnsemblPcellular response to hypoxia
GO:0071283 IEA:EnsemblPcellular response to iron(III) ion
GO:0071407 IEA:EnsemblPcellular response to organic cyclic compound
GO:0048565 IEA:EnsemblPdigestive tract development
GO:0000082 TAS:ReactomePG1/S transition of mitotic cell cycle
GO:0000086 TAS:ReactomePG2/M transition of mitotic cell cycle
GO:0001701 IEA:EnsemblPin utero embryonic development
GO:0000278 TAS:ReactomePmitotic cell cycle
GO:0007080 IMP:BHF-UCLPmitotic metaphase plate congression
GO:0007077 TAS:ReactomePmitotic nuclear envelope disassembly
GO:0071174 IMP:BHF-UCLPmitotic spindle checkpoint
GO:0043148 IMP:BHF-UCLPmitotic spindle stabilization
GO:0010629 IEA:EnsemblPnegative regulation of gene expression
GO:0001933 IEA:EnsemblPnegative regulation of protein phosphorylation
GO:0001556 IEA:EnsemblPoocyte maturation
GO:0051987 IMP:BHF-UCLPpositive regulation of attachment of spindle microtubules to kinetochore
GO:0060045 IEA:EnsemblPpositive regulation of cardiac muscle cell proliferation
GO:0033129 IEA:EnsemblPpositive regulation of histone phosphorylation
GO:0045931 IMP:BHF-UCLPpositive regulation of mitotic cell cycle
GO:0031442 IEA:EnsemblPpositive regulation of mRNA 3'-end processing
GO:0051437 TAS:ReactomePpositive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0006461 IEA:EnsemblPprotein complex assembly
GO:0051726 TAS:ReactomePregulation of cell cycle
GO:0060623 IEA:EnsemblPregulation of chromosome condensation
GO:0000079 IEA:InterProPregulation of cyclin-dependent protein serine/threonine kinase activity
GO:0051439 TAS:ReactomePregulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0046680 IEA:EnsemblPresponse to DDT
GO:0042493 IEA:EnsemblPresponse to drug
GO:0009612 IEA:EnsemblPresponse to mechanical stimulus
GO:0007283 IEA:EnsemblPspermatogenesis
GO:0042246 IEA:EnsemblPtissue regeneration
GO:0055015 IEA:EnsemblPventricular cardiac muscle cell development
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_6954Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
REACT_160122Activation of NIMA Kinases NEK9, NEK6, NEK7
REACT_6820APC/C:Cdc20 mediated degradation of Cyclin B
REACT_6781APC/C:Cdc20 mediated degradation of mitotic proteins
REACT_6828APC/C-mediated degradation of cell cycle proteins
REACT_115566Cell Cycle
REACT_1538Cell Cycle Checkpoints
REACT_152Cell Cycle, Mitotic
REACT_15479Centrosome maturation
REACT_407Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
REACT_150260Condensation of Prometaphase Chromosomes
REACT_264303Condensation of Prophase Chromosomes
REACT_1857Cyclin A/B1 associated events during G2/M transition
REACT_263908Depolymerisation of the Nuclear Lamina
REACT_1321E2F-enabled inhibition of pre-replication complex formation
REACT_471E2F mediated regulation of DNA replication
REACT_1783G1/S Transition
REACT_828G2/M Checkpoints
REACT_897G2/M DNA damage checkpoint
REACT_1846G2/M DNA replication checkpoint
REACT_2203G2/M Transition
REACT_1100Golgi Cisternae Pericentriolar Stack Reorganization
REACT_150182MASTL Facilitates Mitotic Progression
REACT_21267Mitotic G1-G1/S phases
REACT_21391Mitotic G2-G2/M phases
REACT_682Mitotic Prometaphase
REACT_765Mitotic Prophase
REACT_910M Phase
REACT_160255Nuclear Envelope Breakdown
REACT_163931Nuclear Pore Complex (NPC) Disassembly
REACT_6875Phosphorylation of Emi1
REACT_6904Phosphorylation of the APC/C
REACT_1006Polo-like kinase mediated events
REACT_15296Recruitment of mitotic centrosome proteins and complexes
REACT_15510Recruitment of NuMA to mitotic centrosomes
REACT_6837Regulation of APC/C activators between G1/S and early anaphase
REACT_21279Regulation of mitotic cell cycle
REACT_160315Regulation of PLK1 Activity at G2/M Transition
REACT_150425Resolution of Sister Chromatid Cohesion
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