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MGP000439

UniProt Annotations

Entry Information
Gene Namecyclin B1
Protein Entry
UniProt IDP14635
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P14635-1; Sequence=Displayed; Name=2; IsoId=P14635-2; Sequence=VSP_053892; Note=No experimental confirmation available.;
Developmental StageAccumulates steadily during G2 and is abruptly destroyed at mitosis. {ECO:0000269|PubMed:2570636}.
FunctionEssential for the control of the cell cycle at the G2/M (mitosis) transition. {ECO:0000269|PubMed:17495531, ECO:0000269|PubMed:17495533}.
InteractionQ9NPC3:CCNB1IP1; NbExp=2; IntAct=EBI-495332, EBI-745269; P06493:CDK1; NbExp=6; IntAct=EBI-495332, EBI-444308; Q12778:FOXO1; NbExp=2; IntAct=EBI-495332, EBI-1108782; Q99640:PKMYT1; NbExp=4; IntAct=EBI-495332, EBI-495308; P61086:UBE2K; NbExp=2; IntAct=EBI-495332, EBI-473850; Q96PU4:UHRF2; NbExp=2; IntAct=EBI-495332, EBI-625304;
PtmPhosphorylated by PLK1 at Ser-133 on centrosomes during prophase: phosphorylation by PLK1 does not cause nuclear import. Phosphorylation at Ser-147 was also reported to be mediated by PLK1 but Ser-133 seems to be the primary phosphorylation site. {ECO:0000269|PubMed:12447691, ECO:0000269|PubMed:12524548, ECO:0000269|PubMed:18691976}.
PtmUbiquitinated by the SCF(NIPA) complex during interphase, leading to its destruction. Not ubiquitinated during G2/M phases. {ECO:0000269|PubMed:16009132}.
SimilarityBelongs to the cyclin family. Cyclin AB subfamily. {ECO:0000305}.
Subcellular LocationCytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
SubunitInteracts with the CDC2 protein kinase to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF). The cyclin subunit imparts substrate specificity to the complex. Binds HEI10. Interacts with catalytically active RALBP1 and CDC2 during mitosis to form an endocytotic complex during interphase. Interacts with CCNF; interaction is required for nuclear localization. {ECO:0000269|PubMed:10716937, ECO:0000269|PubMed:12612082, ECO:0000269|PubMed:12775724, ECO:0000269|PubMed:17495531, ECO:0000269|PubMed:2570636}.
Web ResourceName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/CCNB1ID951ch5q13.html";
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/ccnb1/";
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