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MGP000442

Record overview

MGPD IDMGP000442
Gene ID896
SpeciesHomo sapiens (Human)
Gene Namecyclin D3
Gene Symbol CCND3
Alternate namesG1/S-specific cyclin-D3; D3-type cyclin; G1/S-specific cyclin D3;
Chromosome6
Map Location6p21
SummaryThe protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activtiy is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. The CDK4 activity associated with this cyclin was reported to be necessary for cell cycle progression through G2 phase into mitosis after UV radiation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
OrthologsView orthologs and multiple alignments for CCND3

Proteins

G1/S-specific cyclin-D3 isoform 1
Refseq ID:NP_001129489
Protein GI:209862835
UniProt ID:P30281
mRNA ID:NM_001136017
Length:211
RefSeq Status:
MNYLDRYLSCVPTRKAQLQLLGAVCMLLASKLRETTPLTIEKLCIYTDHAVSPRQLRDWEVLVLGKLKWDLAAVIAHDFLAFILHRLSLPRDRQALVKKH
AQTFLALCATDYTFAMYPPSMIATGSIGAAVQGLGACSMSGDELTELLAGITGTEVDCLRACQEQIEAALRESLREASQTSSSPAPKAPRGSSSQGPSQT
STPTDVTAIHL
 
G1/S-specific cyclin-D3 isoform 2
Refseq ID:NP_001751
Protein GI:4502619
UniProt ID:P30281
mRNA ID:NM_001760
Length:292
RefSeq Status:
MELLCCEGTRHAPRAGPDPRLLGDQRVLQSLLRLEERYVPRASYFQCVQREIKPHMRKMLAYWMLEVCEEQRCEEEVFPLAMNYLDRYLSCVPTRKAQLQ
LLGAVCMLLASKLRETTPLTIEKLCIYTDHAVSPRQLRDWEVLVLGKLKWDLAAVIAHDFLAFILHRLSLPRDRQALVKKHAQTFLALCATDYTFAMYPP
SMIATGSIGAAVQGLGACSMSGDELTELLAGITGTEVDCLRACQEQIEAALRESLREASQTSSSPAPKAPRGSSSQGPSQTSTPTDVTAIHL
 
G1/S-specific cyclin-D3 isoform 3
Refseq ID:NP_001129597
Protein GI:209915553
UniProt ID:P30281
mRNA ID:NM_001136125
Length:220
RefSeq Status:
MELLCCEGTRHAPRAGPDPRLLGDQRVLQSLLRLEERYVPRASYFQCVQREIKPHMRKMLAYWMLEDWEVLVLGKLKWDLAAVIAHDFLAFILHRLSLPR
DRQALVKKHAQTFLALCATDYTFAMYPPSMIATGSIGAAVQGLGACSMSGDELTELLAGITGTEVDCLRACQEQIEAALRESLREASQTSSSPAPKAPRG
SSSQGPSQTSTPTDVTAIHL
 
G1/S-specific cyclin-D3 isoform 4
Refseq ID:NP_001129598
Protein GI:209915556
UniProt ID:P30281
mRNA ID:NM_001136126
Length:96
RefSeq Status:
MYPPSMIATGSIGAAVQGLGACSMSGDELTELLAGITGTEVDCLRACQEQIEAALRESLREASQTSSSPAPKAPRGSSSQGPSQTSTPTDVTAIHL
 
G1/S-specific cyclin-D3 isoform 4
Refseq ID:NP_001274363
Protein GI:566006202
UniProt ID:P30281
mRNA ID:NM_001287434
Length:96
RefSeq Status:
Protein sequence is identical to GI:209915556 (mRNA isoform)
 
G1/S-specific cyclin-D3 isoform 5
Refseq ID:NP_001274356
Protein GI:566006200
UniProt ID:P30281
mRNA ID:NM_001287427
Length:242
RefSeq Status:
MKSAGGSGRSLLPSPRVCEEQRCEEEVFPLAMNYLDRYLSCVPTRKAQLQLLGAVCMLLASKLRETTPLTIEKLCIYTDHAVSPRQLRDWEVLVLGKLKW
DLAAVIAHDFLAFILHRLSLPRDRQALVKKHAQTFLALCATDYTFAMYPPSMIATGSIGAAVQGLGACSMSGDELTELLAGITGTEVDCLRACQEQIEAA
LRESLREASQTSSSPAPKAPRGSSSQGPSQTSTPTDVTAIHL
 
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