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MGP000442

UniProt Annotations

Entry Information
Gene Namecyclin D3
Protein EntryCCND3_HUMAN
UniProt IDP30281
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=4; Name=1; IsoId=P30281-1; Sequence=Displayed; Name=2; IsoId=P30281-2; Sequence=VSP_042649; Note=No experimental confirmation available.; Name=3; IsoId=P30281-3; Sequence=VSP_046267; Note=No experimental confirmation available.; Name=4; IsoId=P30281-4; Sequence=VSP_046266; Note=No experimental confirmation available.;
FunctionRegulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. {ECO:0000269|PubMed:15358120}.
InteractionO94921:CDK14; NbExp=5; IntAct=EBI-375013, EBI-1043945; P11802:CDK4; NbExp=8; IntAct=EBI-375013, EBI-295644; Q00534:CDK6; NbExp=4; IntAct=EBI-375013, EBI-295663; P38936:CDKN1A; NbExp=4; IntAct=EBI-375013, EBI-375077; P08393:ICP0 (xeno); NbExp=3; IntAct=EBI-375013, EBI-6148881;
PtmPolyubiquitinated by the SCF(FBXL2) complex, leading to proteasomal degradation. {ECO:0000269|PubMed:22020328}.
SimilarityBelongs to the cyclin family. Cyclin D subfamily. {ECO:0000305}.
SimilarityContains 1 cyclin N-terminal domain. {ECO:0000305}.
Subcellular LocationNucleus {ECO:0000269|PubMed:15358120}. Cytoplasm {ECO:0000269|PubMed:15358120}. Membrane {ECO:0000269|PubMed:15358120}. Note=Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated to the nucleus through interaction with KIP/CIP family members. {ECO:0000250}.
SubunitInteracts with the CDK4 and CDK6 protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Interacts with ATF5. Interacts with EIF3K. Component of the ternary complex cyclin D/CDK4/CDKN1B required for nuclear translocation and modulation of CDK4-mediated kinase activity. Can form similar complexes with either CDKN1A or CDKN2A. {ECO:0000269|PubMed:15327989, ECO:0000269|PubMed:15358120, ECO:0000269|PubMed:16782892, ECO:0000269|PubMed:19237555, ECO:0000269|PubMed:9106657}.
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/ccnd3/";
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