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MGP000443

UniProt Annotations

Entry Information
Gene Namecyclin E1
Protein EntryCCNE1_HUMAN
UniProt IDP24864
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=E1L; Synonyms=E-L; IsoId=P24864-1; Sequence=Displayed; Name=E1S; IsoId=P24864-2; Sequence=VSP_001253; Note=Lacks 49 residues within the cyclin box and cannot complex with CDK2.; Name=3; Synonyms=E-S; IsoId=P24864-3; Sequence=VSP_037381;
FunctionEssential for the control of the cell cycle at the G1/S (start) transition. {ECO:0000269|PubMed:7739542}.
InteractionP38398:BRCA1; NbExp=2; IntAct=EBI-519526, EBI-349905; P24941:CDK2; NbExp=10; IntAct=EBI-519526, EBI-375096; P38936:CDKN1A; NbExp=9; IntAct=EBI-519526, EBI-375077; P46527:CDKN1B; NbExp=7; IntAct=EBI-519526, EBI-519280; Q08050:FOXM1; NbExp=2; IntAct=EBI-519526, EBI-866480; Q96PU4:UHRF2; NbExp=4; IntAct=EBI-519526, EBI-625304;
PtmPhosphorylation of both Thr-395 by GSK3 and Ser-399 by CDK2 creates a high affinity degron recognized by FBXW7, and accelerates degradation via the ubiquitin proteasome pathway. Phosphorylation at Thr-77 creates a low affinity degron also recognized by FBXW7. {ECO:0000269|PubMed:14536078, ECO:0000269|PubMed:17434132, ECO:0000269|PubMed:18691976, ECO:0000269|PubMed:21952639, ECO:0000269|PubMed:8861947}.
PtmUbiquitinated by UHRF2; appears to occur independently of phosphorylation. {ECO:0000269|PubMed:21952639}.
SimilarityBelongs to the cyclin family. Cyclin E subfamily. {ECO:0000305}.
Subcellular LocationNucleus {ECO:0000269|PubMed:7739542}.
SubunitInteracts with a member of the CDK2/CDK protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Found in a complex with CDK2, CABLES1 and CCNA1 (By similarity). Part of a complex consisting of UHRF2, CDK2 and CCNE1. Interacts directly with UHRF2; the interaction ubiquitinates CCNE1 and appears to occur independently of CCNE1 phosphorylation. {ECO:0000250, ECO:0000269|PubMed:15178429, ECO:0000269|PubMed:15660127, ECO:0000269|PubMed:17434132, ECO:0000269|PubMed:21952639}.
Tissue SpecificityHighly expressed in testis and placenta. Low levels in bronchial epithelial cells. {ECO:0000269|PubMed:9840943}.
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/ccne1/";
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