MGP Database

MGP000449

Record overview

MGPD ID	MGP000449
Gene ID	915
Species	Homo sapiens (Human)
Gene Name	CD3d molecule, delta (CD3-TCR complex)
Gene Symbol	CD3D
Synonyms	T3D; IMD19; CD3-DELTA;
Alternate names	T-cell surface glycoprotein CD3 delta chain; CD3 delta; OKT3, delta chain; CD3 antigen, delta subunit; T-cell receptor T3 delta chain; CD3d antigen, delta polypeptide (TiT3 complex);
Chromosome	11
Map Location	11q23
Summary	The protein encoded by this gene is part of the T-cell receptor/CD3 complex (TCR/CD3 complex) and is involved in T-cell development and signal transduction. The encoded membrane protein represents the delta subunit of the CD3 complex, and along with four other CD3 subunits, binds either TCR alpha/beta or TCR gamma/delta to form the TCR/CD3 complex on the surface of T-cells. Defects in this gene are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (SCIDBNK). Two transcript variants encoding different isoforms have been found for this gene. Other variants may also exist, but the full-length natures of their transcripts has yet to be defined. [provided by RefSeq, Feb 2009]
Orthologs	View orthologs and multiple alignments for CD3D

Proteins

T-cell surface glycoprotein CD3 delta chain isoform A precursor

Refseq ID:	NP_000723
Protein GI:	4502669
UniProt ID:	P04234
mRNA ID:	NM_000732
Length:	171
RefSeq Status:

`MEHSTFLSGLVLATLLSQVSPFKIPIEELEDRVFVNCNTSITWVEGTVGTLLSDITRLDLGKRILDPRGIYRCNGTDIYKDKESTVQVHYRMCQSCVELD PATVAGIIVTDVIATLLLALGVFCFAGHETGRLSGAADTQALLRNDQVYQPLRDRDDAQYSHLGGNWARNK`

sig_peptide: 1..21
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2231
peptide sequence: 
MEHSTFLSGLVLATLLSQVSP

mat_peptide: 22..171
product: T-cell surface glycoprotein CD3 delta chain isoform A
calculated_mol_wt: 16717
peptide sequence: 
FKIPIEELEDRVFVNCNTSITWVEGTVGTLLSDITRLDLGKRILDPRGIYRCNGTDIYKDKESTVQVHYRMCQSCVELDPATVAGIIVTDVIATLLLALG
VFCFAGHETGRLSGAADTQALLRNDQVYQPLRDRDDAQYSHLGGNWARNK

T-cell surface glycoprotein CD3 delta chain isoform B precursor

Refseq ID:	NP_001035741
Protein GI:	98985801
UniProt ID:	P04234
mRNA ID:	NM_001040651
Length:	127
RefSeq Status:

`MEHSTFLSGLVLATLLSQVSPFKIPIEELEDRVFVNCNTSITWVEGTVGTLLSDITRLDLGKRILDPRGIYRCNGTDIYKDKESTVQVHYRTADTQALLR NDQVYQPLRDRDDAQYSHLGGNWARNK`

sig_peptide: 1..21
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2231
peptide sequence: 
MEHSTFLSGLVLATLLSQVSP

mat_peptide: 22..171
product: T-cell surface glycoprotein CD3 delta chain isoform A
calculated_mol_wt: 16717
peptide sequence: 
FKIPIEELEDRVFVNCNTSITWVEGTVGTLLSDITRLDLGKRILDPRGIYRCNGTDIYKDKESTVQVHYRMCQSCVELDPATVAGIIVTDVIATLLLALG
VFCFAGHETGRLSGAADTQALLRNDQVYQPLRDRDDAQYSHLGGNWARNK

sig_peptide: 1..21
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2231
peptide sequence: 
MEHSTFLSGLVLATLLSQVSP

mat_peptide: 22..127
product: T-cell surface glycoprotein CD3 delta chain isoform B
calculated_mol_wt: 12272
peptide sequence: 
FKIPIEELEDRVFVNCNTSITWVEGTVGTLLSDITRLDLGKRILDPRGIYRCNGTDIYKDKESTVQVHYRTADTQALLRNDQVYQPLRDRDDAQYSHLGG
NWARNK