MGP Database

MGP000450

Record overview

MGPD ID	MGP000450
Gene ID	916
Species	Homo sapiens (Human)
Gene Name	CD3e molecule, epsilon (CD3-TCR complex)
Gene Symbol	CD3E
Synonyms	T3E; TCRE; IMD18;
Alternate names	T-cell surface glycoprotein CD3 epsilon chain; CD3-epsilon; T-cell surface antigen T3/Leu-4 epsilon chain; CD3e antigen, epsilon polypeptide (TiT3 complex); T-cell antigen receptor complex, epsilon subunit of T3;
Chromosome	11
Map Location	11q23
Summary	The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women. [provided by RefSeq, Jul 2008]
Orthologs	View orthologs and multiple alignments for CD3E

Proteins

T-cell surface glycoprotein CD3 epsilon chain precursor

Refseq ID:	NP_000724
Protein GI:	4502671
UniProt ID:	P07766
mRNA ID:	NM_000733
Length:	207
RefSeq Status:

`MQSGTHWRVLGLCLLSVGVWGQDGNEEMGGITQTPYKVSISGTTVILTCPQYPGSEILWQHNDKNIGGDEDDKNIGSDEDHLSLKEFSELEQSGYYVCYP RGSKPEDANFYLYLRARVCENCMEMDVMSVATIVIVDICITGGLLLLVYYWSKNRKAKAKPVTRGAGAGGRQRGQNKERPPPVPNPDYEPIRKGQRDLYS GLNQRRI`

sig_peptide: 1..22
calculated_mol_wt: 2428
peptide sequence: 
MQSGTHWRVLGLCLLSVGVWGQ

mat_peptide: 23..207
product: T-cell surface glycoprotein CD3 epsilon chain
calculated_mol_wt: 20737
peptide sequence: 
DGNEEMGGITQTPYKVSISGTTVILTCPQYPGSEILWQHNDKNIGGDEDDKNIGSDEDHLSLKEFSELEQSGYYVCYPRGSKPEDANFYLYLRARVCENC
MEMDVMSVATIVIVDICITGGLLLLVYYWSKNRKAKAKPVTRGAGAGGRQRGQNKERPPPVPNPDYEPIRKGQRDLYSGLNQRRI