MGP Database

MGP000450

Ontology/Pathway Information

Entrez Gene ID	916
Gene Name	CD3e molecule, epsilon (CD3-TCR complex)
Gene Symbol	CD3E
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0042105	IEA:Ensembl	C	alpha-beta T cell receptor complex
GO:0005911	IEA:Ensembl	C	cell-cell junction
GO:0009897	IDA:MGI	C	external side of plasma membrane
GO:0001772	IEA:Ensembl	C	immunological synapse
GO:0005887	NAS:UniProtKB	C	integral component of plasma membrane
GO:0005886	IDA:MGI	C	plasma membrane
GO:0042101	NAS:UniProtKB	C	T cell receptor complex
GO:0046982	IPI:UniProtKB	F	protein heterodimerization activity
GO:0019901	NAS:UniProtKB	F	protein kinase binding
GO:0030159	NAS:UniProtKB	F	receptor signaling complex scaffold activity
GO:0005057	TAS:ProtInc	F	receptor signaling protein activity
GO:0017124	IPI:UniProtKB	F	SH3 domain binding
GO:0042608	NAS:UniProtKB	F	T cell receptor binding
GO:0004888	NAS:UniProtKB	F	transmembrane signaling receptor activity
GO:0097190	IEA:Ensembl	P	apoptotic signaling pathway
GO:0007166	NAS:UniProtKB	P	cell surface receptor signaling pathway
GO:0007186	TAS:ProtInc	P	G-protein coupled receptor signaling pathway
GO:0035556	TAS:GOC	P	intracellular signal transduction
GO:0045879	IEA:Ensembl	P	negative regulation of smoothened signaling pathway
GO:0045060	IEA:Ensembl	P	negative thymic T cell selection
GO:0046641	IEA:Ensembl	P	positive regulation of alpha-beta T cell proliferation
GO:0050850	IEA:Ensembl	P	positive regulation of calcium-mediated signaling
GO:0032729	IEA:Ensembl	P	positive regulation of interferon-gamma production
GO:0045086	IEA:Ensembl	P	positive regulation of interleukin-2 biosynthetic process
GO:0032753	IEA:Ensembl	P	positive regulation of interleukin-4 production
GO:0050731	IEA:Ensembl	P	positive regulation of peptidyl-tyrosine phosphorylation
GO:0002669	IEA:Ensembl	P	positive regulation of T cell anergy
GO:0042102	IMP:UniProtKB	P	positive regulation of T cell proliferation
GO:0006461	NAS:UniProtKB	P	protein complex assembly
GO:0042981	NAS:UniProtKB	P	regulation of apoptotic process
GO:0050776	TAS:Reactome	P	regulation of immune response
GO:0007584	IEA:Ensembl	P	response to nutrient
GO:0007172	TAS:ProtInc	P	signal complex assembly
GO:0042110	NAS:UniProtKB	P	T cell activation
GO:0031295	TAS:Reactome	P	T cell costimulation
GO:0050852	TAS:Reactome	P	T cell receptor signaling pathway
GO:0007169	TAS:ProtInc	P	transmembrane receptor protein tyrosine kinase signaling pathway

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_75774	Adaptive Immune System
REACT_19344	Costimulation by the CD28 family
REACT_12555	Downstream TCR signaling
REACT_12623	Generation of second messenger molecules
REACT_6900	Immune System
REACT_11152	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
REACT_19324	PD-1 signaling
REACT_12582	Phosphorylation of CD3 and TCR zeta chains
REACT_12526	TCR signaling
REACT_12596	Translocation of ZAP-70 to Immunological synapse