MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP000451

Record overview

MGPD IDMGP000451
Gene ID917
SpeciesHomo sapiens (Human)
Gene NameCD3g molecule, gamma (CD3-TCR complex)
Gene Symbol CD3G
SynonymsT3G; IMD17; CD3-GAMMA;
Alternate namesT-cell surface glycoprotein CD3 gamma chain; T-cell receptor T3 gamma chain; CD3g molecule, epsilon (CD3-TCR complex); CD3g antigen, gamma polypeptide (TiT3 complex); T-cell antigen receptor complex, gamma subunit of T3;
Chromosome11
Map Location11q23
SummaryThe protein encoded by this gene is the CD3-gamma polypeptide, which together with CD3-epsilon, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. Defects in this gene are associated with T cell immunodeficiency. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for CD3G

Proteins

T-cell surface glycoprotein CD3 gamma chain precursor
Refseq ID:NP_000064
Protein GI:4557429
UniProt ID:P09693
mRNA ID:NM_000073
Length:182
RefSeq Status:
MEQGKGLAVLILAIILLQGTLAQSIKGNHLVKVYDYQEDGSVLLTCDAEAKNITWFKDGKMIGFLTEDKKKWNLGSNAKDPRGMYQCKGSQNKSKPLQVY
YRMCQNCIELNAATISGFLFAEIVSIFVLAVGVYFIAGQDGVRQSRASDKQTLLPNDQLYQPLKDREDDQYSHLQGNQLRRN
 
sig_peptide: 1..22
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2266
peptide sequence: 
MEQGKGLAVLILAIILLQGTLA

mat_peptide: 23..182
product: T-cell surface glycoprotein CD3 gamma chain
calculated_mol_wt: 18222
peptide sequence: 
QSIKGNHLVKVYDYQEDGSVLLTCDAEAKNITWFKDGKMIGFLTEDKKKWNLGSNAKDPRGMYQCKGSQNKSKPLQVYYRMCQNCIELNAATISGFLFAE
IVSIFVLAVGVYFIAGQDGVRQSRASDKQTLLPNDQLYQPLKDREDDQYSHLQGNQLRRN
 
  logo