MGP Database

MGP000453

Record overview

MGPD ID	MGP000453
Gene ID	925
Species	Homo sapiens (Human)
Gene Name	CD8a molecule
Gene Symbol	CD8A
Synonyms	CD8; MAL; p32; Leu2;
Alternate names	T-cell surface glycoprotein CD8 alpha chain; T8 T-cell antigen; T cell co-receptor; OKT8 T-cell antigen; T-cell antigen Leu2; Leu2 T-lymphocyte antigen; CD8 antigen, alpha polypeptide (p32); T-lymphocyte differentiation antigen T8/Leu-2;
Chromosome	2
Map Location	2p12
Summary	The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Orthologs	View orthologs and multiple alignments for CD8A

Proteins

T-cell surface glycoprotein CD8 alpha chain isoform 1 precursor

Refseq ID:	NP_001139345
Protein GI:	225007536
UniProt ID:	P01732
mRNA ID:	NM_001145873
Length:	235
RefSeq Status:

`MALPVTALLLPLALLLHAARPSQFRVSPLDRTWNLGETVELKCQVLLSNPTSGCSWLFQPRGAAASPTFLLYLSQNKPKAAEGLDTQRFSGKRLGDTFVL TLSDFRRENEGYYFCSALSNSIMYFSHFVPVFLPAKPTTTPAPRPPTPAPTIASQPLSLRPEACRPAAGGAVHTRGLDFACDIYIWAPLAGTCGVLLLSL VITLYCNHRNRRRVCKCPRPVVKSGDKPSLSARYV`

sig_peptide: 1..21
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2195
peptide sequence: 
MALPVTALLLPLALLLHAARP

sig_peptide: 1..21
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2195
peptide sequence: 
MALPVTALLLPLALLLHAARP

mat_peptide: 22..235
product: T-cell surface glycoprotein CD8 alpha chain isoform 1
calculated_mol_wt: 23552
peptide sequence: 
SQFRVSPLDRTWNLGETVELKCQVLLSNPTSGCSWLFQPRGAAASPTFLLYLSQNKPKAAEGLDTQRFSGKRLGDTFVLTLSDFRRENEGYYFCSALSNS
IMYFSHFVPVFLPAKPTTTPAPRPPTPAPTIASQPLSLRPEACRPAAGGAVHTRGLDFACDIYIWAPLAGTCGVLLLSLVITLYCNHRNRRRVCKCPRPV
VKSGDKPSLSARYV

sig_peptide: 1..21
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2195
peptide sequence: 
MALPVTALLLPLALLLHAARP

mat_peptide: 22..235
product: T-cell surface glycoprotein CD8 alpha chain isoform 1
calculated_mol_wt: 23552
peptide sequence: 
SQFRVSPLDRTWNLGETVELKCQVLLSNPTSGCSWLFQPRGAAASPTFLLYLSQNKPKAAEGLDTQRFSGKRLGDTFVLTLSDFRRENEGYYFCSALSNS
IMYFSHFVPVFLPAKPTTTPAPRPPTPAPTIASQPLSLRPEACRPAAGGAVHTRGLDFACDIYIWAPLAGTCGVLLLSLVITLYCNHRNRRRVCKCPRPV
VKSGDKPSLSARYV

T-cell surface glycoprotein CD8 alpha chain isoform 1 precursor

Refseq ID:	NP_001759
Protein GI:	22902134
UniProt ID:	P01732
mRNA ID:	NM_001768
Length:	235
RefSeq Status:

Protein sequence is identical to GI:225007536 (mRNA isoform)

sig_peptide: 1..21
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2195
peptide sequence: 
MALPVTALLLPLALLLHAARP

sig_peptide: 1..21
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2195
peptide sequence: 
MALPVTALLLPLALLLHAARP

mat_peptide: 22..235
product: T-cell surface glycoprotein CD8 alpha chain isoform 1
calculated_mol_wt: 23552
peptide sequence: 
SQFRVSPLDRTWNLGETVELKCQVLLSNPTSGCSWLFQPRGAAASPTFLLYLSQNKPKAAEGLDTQRFSGKRLGDTFVLTLSDFRRENEGYYFCSALSNS
IMYFSHFVPVFLPAKPTTTPAPRPPTPAPTIASQPLSLRPEACRPAAGGAVHTRGLDFACDIYIWAPLAGTCGVLLLSLVITLYCNHRNRRRVCKCPRPV
VKSGDKPSLSARYV

T-cell surface glycoprotein CD8 alpha chain isoform 2 precursor

Refseq ID:	NP_741969
Protein GI:	27886642
UniProt ID:	P01732
mRNA ID:	NM_171827
Length:	198
RefSeq Status:

`MALPVTALLLPLALLLHAARPSQFRVSPLDRTWNLGETVELKCQVLLSNPTSGCSWLFQPRGAAASPTFLLYLSQNKPKAAEGLDTQRFSGKRLGDTFVL TLSDFRRENEGYYFCSALSNSIMYFSHFVPVFLPAKPTTTPAPRPPTPAPTIASQPLSLRPEACRPAAGGAGNRRRVCKCPRPVVKSGDKPSLSARYV`

`sig_peptide: 1..21 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2195 peptide sequence: MALPVTALLLPLALLLHAARP`