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MGP000453

UniProt Annotations

Entry Information
Gene NameCD8a molecule
Protein EntryCD8A_HUMAN
UniProt IDP01732
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; Synonyms=membrane, mCD8alpha; IsoId=P01732-1; Sequence=Displayed; Name=2; Synonyms=secreted, sCD8alpha; IsoId=P01732-2; Sequence=VSP_012653; Name=3; IsoId=P01732-3; Sequence=VSP_054438; Note=No experimental confirmation available.;
DiseaseCD8 deficiency, familial (CD8 deficiency) [MIM:608957]: An immunologic defect characterized by absence of CD8+ cells, leading to recurrent bacterial infections. {ECO:0000269|PubMed:11435463}. Note=The disease is caused by mutations affecting the gene represented in this entry.
FunctionIdentifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains.
PtmAll of the five most C-terminal cysteines form inter-chain disulfide bonds in dimers and higher multimers, while the four N- terminal cysteines do not. {ECO:0000250}.
SimilarityContains 1 Ig-like V-type (immunoglobulin-like) domain. {ECO:0000305}.
Subcellular LocationIsoform 1: Cell membrane; Single-pass type I membrane protein.
Subcellular LocationIsoform 2: Secreted.
SubunitIn general heterodimer of an alpha and a beta chain linked by two disulfide bonds. Can also form homodimers. Shown to be expressed as heterodimer on thymocytes and as homodimer on peripheral blood T-lymphocytes. Interacts with the MHC class I HLA-A/B2M dimer. Interacts with LCK in a zinc-dependent manner. {ECO:0000269|PubMed:14500983, ECO:0000269|PubMed:6605969, ECO:0000269|PubMed:9177355}.
Web ResourceName=CD8Abase; Note=CD8A mutation db; URL="http://structure.bmc.lu.se/idbase/CD8Abase/";
Web ResourceName=Wikipedia; Note=CD8 entry; URL="http://en.wikipedia.org/wiki/CD8";
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