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MGP000467

UniProt Annotations

Entry Information
Gene NameCD58 molecule
Protein EntryLFA3_HUMAN
UniProt IDP19256
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; Synonyms=Long; IsoId=P19256-1; Sequence=Displayed; Name=2; Synonyms=Short; IsoId=P19256-2; Sequence=VSP_002522, VSP_002523; Note=GPI-anchor amidated asparagine on Asn-235. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; Name=3; IsoId=P19256-3; Sequence=VSP_038693;
FunctionLigand of the T-lymphocyte CD2 glycoprotein. This interaction is important in mediating thymocyte interactions with thymic epithelial cells, antigen-independent and -dependent interactions of T-lymphocytes with target cells and antigen- presenting cells and the T-lymphocyte rosetting with erythrocytes. In addition, the LFA-3/CD2 interaction may prime response by both the CD2+ and LFA-3+ cells.
SimilarityContains 1 Ig-like C2-type (immunoglobulin-like) domain. {ECO:0000305}.
Subcellular LocationIsoform 1: Cell membrane; Single-pass type I membrane protein.
Subcellular LocationIsoform 2: Cell membrane; Lipid-anchor, GPI- anchor.
SubunitInteracts with CD2. {ECO:0000269|PubMed:10380930, ECO:0000269|PubMed:3309127}.
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