MGP Database

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MGP000471

Record overview

MGPD IDMGP000471
Gene ID972
SpeciesHomo sapiens (Human)
Gene NameCD74 molecule, major histocompatibility complex, class II invariant chain
Gene Symbol CD74
SynonymsII; DHLAG; HLADG; Ia-GAMMA;
Alternate namesHLA class II histocompatibility antigen gamma chain; p33; HLA-DR-gamma; MHC HLA-DR gamma chain; Ia-associated invariant chain; gamma chain of class II antigens; HLA-DR antigens-associated invariant chain; CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated);
Chromosome5
Map Location5q32
SummaryThe protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
OrthologsView orthologs and multiple alignments for CD74

Proteins

HLA class II histocompatibility antigen gamma chain isoform a
Refseq ID:NP_001020330
Protein GI:68448544
UniProt ID:P04233
mRNA ID:NM_001025159
Length:296
RefSeq Status:
MHRRRSRSCREDQKPVMDDQRDLISNNEQLPMLGRRPGAPESKCSRGALYTGFSILVTLLLAGQATTAYFLYQQQGRLDKLTVTSQNLQLENLRMKLPKP
PKPVSKMRMATPLLMQALPMGALPQGPMQNATKYGNMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKNTMETIDWKVFESWMHHWLLFEMSRHSLEQ
KPTDAPPKVLTKCQEEVSHIPAVHPGSFRPKCDENGNYLPLQCYGSIGYCWCVFPNGTEVPNTRSRGHHNCSESLELEDPSSGLGVTKQDLGPVPM
 
HLA class II histocompatibility antigen gamma chain isoform b
Refseq ID:NP_004346
Protein GI:10835071
UniProt ID:P04233
mRNA ID:NM_004355
Length:232
RefSeq Status:
MHRRRSRSCREDQKPVMDDQRDLISNNEQLPMLGRRPGAPESKCSRGALYTGFSILVTLLLAGQATTAYFLYQQQGRLDKLTVTSQNLQLENLRMKLPKP
PKPVSKMRMATPLLMQALPMGALPQGPMQNATKYGNMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKNTMETIDWKVFESWMHHWLLFEMSRHSLEQ
KPTDAPPKESLELEDPSSGLGVTKQDLGPVPM
 
HLA class II histocompatibility antigen gamma chain isoform c
Refseq ID:NP_001020329
Protein GI:68448537
UniProt ID:P04233
mRNA ID:NM_001025158
Length:160
RefSeq Status:
MHRRRSRSCREDQKPVMDDQRDLISNNEQLPMLGRRPGAPESKCSRGALYTGFSILVTLLLAGQATTAYFLYQQQGRLDKLTVTSQNLQLENLRMKLPKP
PKPVSKMRMATPLLMQALPMGALPQGPMQNATKYGNMTEDHVMHLLQSHWNWRTRLLGWV
 
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