MGP Database

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MGP000471

Ontology/Pathway Information

Entrez Gene ID972
Gene NameCD74 molecule, major histocompatibility complex, class II invariant chain
Gene Symbol CD74
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0009986 IDA:BHF-UCLCcell surface
GO:0030669 TAS:ReactomeCclathrin-coated endocytic vesicle membrane
GO:0030666 TAS:ReactomeCendocytic vesicle membrane
GO:0012507 TAS:ReactomeCER to Golgi transport vesicle membrane
GO:0009897 IEA:EnsemblCexternal side of plasma membrane
GO:0070062 IDA:UniProtKBCextracellular vesicular exosome
GO:0000139 TAS:ReactomeCGolgi membrane
GO:0071556 TAS:ReactomeCintegral component of lumenal side of endoplasmic reticulum membrane
GO:0016021 IDA:BHF-UCLCintegral component of membrane
GO:0005622 TAS:UniProtKBCintracellular
GO:0043202 TAS:ReactomeClysosomal lumen
GO:0005765 TAS:ReactomeClysosomal membrane
GO:0035692 IDA:BHF-UCLCmacrophage migration inhibitory factor receptor complex
GO:0016020 IDA:UniProtKBCmembrane
GO:0042613 IEA:EnsemblCMHC class II protein complex
GO:0005771 IEA:EnsemblCmultivesicular body
GO:0035693 IEA:EnsemblCNOS2-CD74 complex
GO:0005886 TAS:ReactomeCplasma membrane
GO:0032588 TAS:ReactomeCtrans-Golgi network membrane
GO:0030658 TAS:ReactomeCtransport vesicle membrane
GO:0005773 IDA:BHF-UCLCvacuole
GO:0001540 IPI:BHF-UCLFbeta-amyloid binding
GO:0019955 IPI:UniProtKBFcytokine binding
GO:0004896 IDA:BHF-UCLFcytokine receptor activity
GO:0042802 TAS:UniProtKBFidentical protein binding
GO:0035718 IPI:BHF-UCLFmacrophage migration inhibitory factor binding
GO:0042289 NAS:UniProtKBFMHC class II protein binding
GO:0042658 IDA:UniProtKBFMHC class II protein binding, via antigen binding groove
GO:0023026 IDA:UniProtKBFMHC class II protein complex binding
GO:0044183 IDA:UniProtKBFprotein binding involved in protein folding
GO:0000187 IEA:EnsemblPactivation of MAPK activity
GO:0019883 NAS:UniProtKBPantigen processing and presentation of endogenous antigen
GO:0019886 TAS:ReactomePantigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0008283 IDA:UniProtKBPcell proliferation
GO:0051085 IEA:EnsemblPchaperone mediated protein folding requiring cofactor
GO:0006952 IEA:EnsemblPdefense response
GO:0016064 ISS:UniProtKBPimmunoglobulin mediated immune response
GO:0006886 ISS:UniProtKBPintracellular protein transport
GO:0035691 IEA:EnsemblPmacrophage migration inhibitory factor signaling pathway
GO:0043066 IDA:UniProtKBPnegative regulation of apoptotic process
GO:0043518 IDA:BHF-UCLPnegative regulation of DNA damage response, signal transduction by p53 class mediator
GO:1902166 IMP:BHF-UCLPnegative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0002906 IEA:EnsemblPnegative regulation of mature B cell apoptotic process
GO:0002792 IDA:BHF-UCLPnegative regulation of peptide secretion
GO:0045581 IEA:EnsemblPnegative regulation of T cell differentiation
GO:0045060 IEA:EnsemblPnegative thymic T cell selection
GO:0030890 IMP:BHF-UCLPpositive regulation of B cell proliferation
GO:2000343 ISS:BHF-UCLPpositive regulation of chemokine (C-X-C motif) ligand 2 production
GO:0001961 IMP:BHF-UCLPpositive regulation of cytokine-mediated signaling pathway
GO:0002606 IEA:EnsemblPpositive regulation of dendritic cell antigen processing and presentation
GO:0070374 IDA:BHF-UCLPpositive regulation of ERK1 and ERK2 cascade
GO:0048146 IMP:BHF-UCLPpositive regulation of fibroblast proliferation
GO:0060907 ISS:BHF-UCLPpositive regulation of macrophage cytokine production
GO:0090023 ISS:BHF-UCLPpositive regulation of neutrophil chemotaxis
GO:0050731 IDA:BHF-UCLPpositive regulation of peptidyl-tyrosine phosphorylation
GO:0045582 IEA:EnsemblPpositive regulation of T cell differentiation
GO:0002830 IEA:EnsemblPpositive regulation of type 2 immune response
GO:0045059 IEA:EnsemblPpositive thymic T cell selection
GO:0001516 IDA:UniProtKBPprostaglandin biosynthetic process
GO:0006461 ISS:UniProtKBPprotein complex assembly
GO:0043030 NAS:UniProtKBPregulation of macrophage activation
GO:0007165 IDA:UniProtKBPsignal transduction
GO:0045058 NAS:UniProtKBPT cell selection
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_75774Adaptive Immune System
REACT_6900Immune System
REACT_121399MHC class II antigen presentation
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