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MGP000473

UniProt Annotations

Entry Information

Gene Name	CD79b molecule, immunoglobulin-associated beta
Protein Entry	CD79B_HUMAN
UniProt ID	P40259
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=3; Name=Long; IsoId=P40259-1; Sequence=Displayed; Name=Short; IsoId=P40259-2; Sequence=VSP_002477; Name=3; IsoId=P40259-3; Sequence=VSP_047222; Note=No experimental confirmation available.;
Disease	Agammaglobulinemia 6, autosomal recessive (AGM6) [MIM:612692]: A primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B-cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life. {ECO:0000269\|PubMed:17675462}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Function	Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation. {ECO:0000269\|PubMed:12097390, ECO:0000269\|PubMed:8617796, ECO:0000269\|PubMed:9057631}.
Ptm	Phosphorylated on tyrosine upon B-cell activation by SRC-type Tyr-kinases such as BLK, LYN and SYK.
Similarity	Contains 1 Ig-like V-type (immunoglobulin-like) domain. {ECO:0000305}.
Similarity	Contains 1 ITAM domain. {ECO:0000255\|PROSITE- ProRule:PRU00379}.
Subcellular Location	Cell membrane; Single-pass type I membrane protein. Note=Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts. {ECO:0000250}.
Subunit	Heterodimer of alpha and beta chains; disulfide-linked. Part of the B-cell antigen receptor complex where the alpha/beta chain heterodimer is non-covalently associated with an antigen- specific membrane-bound surface immunoglobulin of two heavy chains and two light chains. Interacts with LYN (By similarity). {ECO:0000250}.
Tissue Specificity	B-cells.
Web Resource	Name=CD79Bbase; Note=CD79B mutation db; URL="http://structure.bmc.lu.se/idbase/CD79Bbase/";