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MGP000477

UniProt Annotations

Entry Information
Gene Namecytidine deaminase
Protein Entry
UniProt IDP32320
SpeciesHuman
Comments
Comment typeDescription
Catalytic Activity2'deoxycytidine + H(2)O = 2'-deoxyuridine + NH(3).
Catalytic ActivityCytidine + H(2)O = uridine + NH(3).
CofactorName=Zn(2+); Xref=ChEBI:CHEBI:29105;
FunctionThis enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.
SimilarityBelongs to the cytidine and deoxycytidylate deaminase family. {ECO:0000305}.
SimilarityContains 1 CMP/dCMP deaminase zinc-binding domain. {ECO:0000305}.
SubunitHomotetramer. {ECO:0000269|PubMed:15689149}.
Tissue SpecificityHighly expressed in granulocytes while expression is very low in fibroblasts, chondrocytes, monocytes, and T- as well as B-cell lines.
Web ResourceName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/CDAID998ch1p36.html";
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