MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP000478

Ontology/Pathway Information

Entrez Gene ID983
Gene Namecyclin-dependent kinase 1
Gene Symbol CDK1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005813 IDA:UniProtKBCcentrosome
GO:0005737 IDA:HPACcytoplasm
GO:0005829 TAS:ReactomeCcytosol
GO:0070062 IDA:UniProtKBCextracellular vesicular exosome
GO:0016020 IDA:UniProtKBCmembrane
GO:0030496 IDA:UniProtKBCmidbody
GO:0005739 TAS:UniProtKBCmitochondrion
GO:0072686 IDA:UniProtKBCmitotic spindle
GO:0005654 TAS:ReactomeCnucleoplasm
GO:0005634 IDA:HPACnucleus
GO:0005876 IDA:UniProtKBCspindle microtubule
GO:0005524 IEA:UniProtKB-KWFATP binding
GO:0004693 IDA:UniProtKBFcyclin-dependent protein serine/threonine kinase activity
GO:0035173 IEA:EnsemblFhistone kinase activity
GO:0004672 NAS:ProtIncFprotein kinase activity
GO:0004674 IDA:ParkinsonsUK-UCLFprotein serine/threonine kinase activity
GO:0008353 IDA:UniProtKBFRNA polymerase II carboxy-terminal domain kinase activity
GO:0000187 TAS:ReactomePactivation of MAPK activity
GO:0000186 TAS:ReactomePactivation of MAPKK activity
GO:0031145 TAS:ReactomePanaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0006915 IEA:UniProtKB-KWPapoptotic process
GO:0007411 TAS:ReactomePaxon guidance
GO:0007569 IEA:EnsemblPcell aging
GO:0051301 IEA:UniProtKB-KWPcell division
GO:0016477 TAS:UniProtKBPcell migration
GO:0070301 IEA:EnsemblPcellular response to hydrogen peroxide
GO:0007098 TAS:UniProtKBPcentrosome cycle
GO:0030261 IEA:EnsemblPchromosome condensation
GO:0006281 TAS:UniProtKBPDNA repair
GO:0006260 TAS:UniProtKBPDNA replication
GO:0007173 TAS:ReactomePepidermal growth factor receptor signaling pathway
GO:0030855 IEP:UniProtKBPepithelial cell differentiation
GO:0038095 TAS:ReactomePFc-epsilon receptor signaling pathway
GO:0008543 TAS:ReactomePfibroblast growth factor receptor signaling pathway
GO:0000082 TAS:ReactomePG1/S transition of mitotic cell cycle
GO:0000086 TAS:ReactomePG2/M transition of mitotic cell cycle
GO:0045087 TAS:ReactomePinnate immune response
GO:0008286 TAS:ReactomePinsulin receptor signaling pathway
GO:0000165 TAS:ReactomePMAPK cascade
GO:0000226 TAS:UniProtKBPmicrotubule cytoskeleton organization
GO:0000278 TAS:ReactomePmitotic cell cycle
GO:0007095 IEA:EnsemblPmitotic G2 DNA damage checkpoint
GO:0007067 IEA:UniProtKB-KWPmitotic nuclear division
GO:0007077 TAS:ReactomePmitotic nuclear envelope disassembly
GO:0002755 TAS:ReactomePMyD88-dependent toll-like receptor signaling pathway
GO:0002756 TAS:ReactomePMyD88-independent toll-like receptor signaling pathway
GO:0043066 IDA:UniProtKBPnegative regulation of apoptotic process
GO:0048011 TAS:ReactomePneurotrophin TRK receptor signaling pathway
GO:0031100 IEA:EnsemblPorgan regeneration
GO:0018105 IDA:ParkinsonsUK-UCLPpeptidyl-serine phosphorylation
GO:0018107 IDA:ParkinsonsUK-UCLPpeptidyl-threonine phosphorylation
GO:0060045 IEA:EnsemblPpositive regulation of cardiac muscle cell proliferation
GO:0045740 IEA:EnsemblPpositive regulation of DNA replication
GO:0010628 IEA:EnsemblPpositive regulation of gene expression
GO:0045931 IEA:EnsemblPpositive regulation of mitotic cell cycle
GO:0033160 IEA:EnsemblPpositive regulation of protein import into nucleus, translocation
GO:0051437 TAS:ReactomePpositive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0007344 TAS:UniProtKBPpronuclear fusion
GO:0006461 IEA:EnsemblPprotein complex assembly
GO:0034501 IDA:BHF-UCLPprotein localization to kinetochore
GO:0007265 TAS:ReactomePRas protein signal transduction
GO:0045995 TAS:UniProtKBPregulation of embryonic development
GO:0014038 TAS:UniProtKBPregulation of Schwann cell differentiation
GO:0000083 TAS:ReactomePregulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0051439 TAS:ReactomePregulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0014823 IEA:EnsemblPresponse to activity
GO:0014075 IEA:EnsemblPresponse to amine
GO:0048678 IEA:EnsemblPresponse to axon injury
GO:0046686 IEA:EnsemblPresponse to cadmium ion
GO:0046688 IEA:EnsemblPresponse to copper ion
GO:0042493 IEA:EnsemblPresponse to drug
GO:0045471 IEA:EnsemblPresponse to ethanol
GO:0014070 IEA:EnsemblPresponse to organic cyclic compound
GO:0009636 IEA:EnsemblPresponse to toxic substance
GO:0007264 TAS:ReactomePsmall GTPase mediated signal transduction
GO:0051403 TAS:ReactomePstress-activated MAPK cascade
GO:0034166 TAS:ReactomePtoll-like receptor 10 signaling pathway
GO:0034134 TAS:ReactomePtoll-like receptor 2 signaling pathway
GO:0034138 TAS:ReactomePtoll-like receptor 3 signaling pathway
GO:0034142 TAS:ReactomePtoll-like receptor 4 signaling pathway
GO:0034146 TAS:ReactomePtoll-like receptor 5 signaling pathway
GO:0034162 TAS:ReactomePtoll-like receptor 9 signaling pathway
GO:0002224 TAS:ReactomePtoll-like receptor signaling pathway
GO:0038123 TAS:ReactomePtoll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 TAS:ReactomePtoll-like receptor TLR6:TLR2 signaling pathway
GO:0035666 TAS:ReactomePTRIF-dependent toll-like receptor signaling pathway
GO:0055015 IEA:EnsemblPventricular cardiac muscle cell development
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_6890Activated TLR4 signalling
REACT_6954Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
REACT_160122Activation of NIMA Kinases NEK9, NEK6, NEK7
REACT_267965Anchoring of the basal body to the plasma membrane
REACT_6820APC/C:Cdc20 mediated degradation of Cyclin B
REACT_6781APC/C:Cdc20 mediated degradation of mitotic proteins
REACT_267701APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
REACT_6828APC/C-mediated degradation of cell cycle proteins
REACT_12002ARMS-mediated activation
REACT_268265Assembly of the primary cilium
REACT_18266Axon guidance
REACT_6850Cdc20:Phospho-APC/C mediated degradation of Cyclin A
REACT_115566Cell Cycle
REACT_1538Cell Cycle Checkpoints
REACT_152Cell Cycle, Mitotic
REACT_15479Centrosome maturation
REACT_407Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
REACT_150260Condensation of Prometaphase Chromosomes
REACT_264303Condensation of Prophase Chromosomes
REACT_1857Cyclin A/B1 associated events during G2/M transition
REACT_2101Cyclin B2 mediated events
REACT_75790Cytokine Signaling in Immune system
REACT_147694DAP12 interactions
REACT_147814DAP12 signaling
REACT_263908Depolymerisation of the Nuclear Lamina
REACT_111045Developmental Biology
REACT_116125Disease
REACT_21272Downstream signaling of activated FGFR
REACT_17025Downstream signal transduction
REACT_1321E2F-enabled inhibition of pre-replication complex formation
REACT_471E2F mediated regulation of DNA replication
REACT_1391ERK1 activation
REACT_1482ERK activation
REACT_163936Fc epsilon receptor (FCERI) signaling
REACT_163701FCERI mediated MAPK activation
REACT_12076Frs2-mediated activation
REACT_21247FRS2-mediated cascade
REACT_111214G0 and Early G1
REACT_683G1/S-Specific Transcription
REACT_1783G1/S Transition
REACT_828G2/M Checkpoints
REACT_897G2/M DNA damage checkpoint
REACT_1846G2/M DNA replication checkpoint
REACT_2203G2/M Transition
REACT_120966Gastrin-CREB signalling pathway via PKC and MAPK
REACT_1100Golgi Cisternae Pericentriolar Stack Reorganization
REACT_12606GRB2 events in EGFR signaling
REACT_115854GRB2 events in ERBB2 signaling
REACT_150210IGF1R signaling cascade
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_1195Insulin receptor signalling cascade
REACT_27283Interleukin-2 signaling
REACT_332IRS-mediated signalling
REACT_762IRS-related events
REACT_150203IRS-related events triggered by IGF1R
REACT_15364Loss of Nlp from mitotic centrosomes
REACT_15451Loss of proteins required for interphase microtubule organization from the centrosome
REACT_21308MAP kinase activation in TLR cascade
REACT_150182MASTL Facilitates Mitotic Progression
REACT_21267Mitotic G1-G1/S phases
REACT_21391Mitotic G2-G2/M phases
REACT_682Mitotic Prometaphase
REACT_765Mitotic Prophase
REACT_910M Phase
REACT_27215MyD88 cascade initiated on plasma membrane
REACT_25222MyD88 dependent cascade initiated on endosome
REACT_6809MyD88-independent cascade
REACT_6788MyD88:Mal cascade initiated on plasma membrane
REACT_18334NCAM signaling for neurite out-growth
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_160255Nuclear Envelope Breakdown
REACT_163931Nuclear Pore Complex (NPC) Disassembly
REACT_264135Organelle biogenesis and maintenance
REACT_6875Phosphorylation of Emi1
REACT_6362Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes
REACT_6904Phosphorylation of the APC/C
REACT_12005Prolonged ERK activation events
REACT_634RAF/MAP kinase cascade
REACT_15296Recruitment of mitotic centrosome proteins and complexes
REACT_15510Recruitment of NuMA to mitotic centrosomes
REACT_6837Regulation of APC/C activators between G1/S and early anaphase
REACT_21279Regulation of mitotic cell cycle
REACT_160315Regulation of PLK1 Activity at G2/M Transition
REACT_150425Resolution of Sister Chromatid Cohesion
REACT_12579SHC1 events in EGFR signaling
REACT_115993SHC1 events in ERBB2 signaling
REACT_116005SHC1 events in ERBB4 signaling
REACT_661SHC-mediated signalling
REACT_999SHC-related events
REACT_150139SHC-related events triggered by IGF1R
REACT_9417Signaling by EGFR
REACT_115871Signaling by EGFR in Cancer
REACT_268269Signaling by EGFRvIII in Cancer
REACT_115755Signaling by ERBB2
REACT_115596Signaling by ERBB4
REACT_9470Signaling by FGFR
REACT_120736Signaling by FGFR in disease
REACT_14797Signaling by GPCR
REACT_498Signaling by Insulin receptor
REACT_22232Signaling by Interleukins
REACT_169118Signaling by Leptin
REACT_268006Signaling by Ligand-Responsive EGFR Variants in Cancer
REACT_268546Signaling by Overexpressed Wild-Type EGFR in Cancer
REACT_16888Signaling by PDGF
REACT_111040Signaling by SCF-KIT
REACT_150359Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
REACT_12529Signaling by VEGF
REACT_11061Signalling by NGF
REACT_12058Signalling to ERKs
REACT_12077Signalling to p38 via RIT and RIN
REACT_12033Signalling to RAS
REACT_111102Signal Transduction
REACT_524SOS-mediated signalling
REACT_9027Toll Like Receptor 10 (TLR10) Cascade
REACT_7980Toll Like Receptor 2 (TLR2) Cascade
REACT_6783Toll Like Receptor 3 (TLR3) Cascade
REACT_6894Toll Like Receptor 4 (TLR4) Cascade
REACT_9061Toll Like Receptor 5 (TLR5) Cascade
REACT_9020Toll Like Receptor 7/8 (TLR7/8) Cascade
REACT_9047Toll Like Receptor 9 (TLR9) Cascade
REACT_6966Toll-Like Receptors Cascades
REACT_8005Toll Like Receptor TLR1:TLR2 Cascade
REACT_8006Toll Like Receptor TLR6:TLR2 Cascade
REACT_25024TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
REACT_25281TRIF-mediated TLR3/TLR4 signaling
REACT_264464VEGFA-VEGFR2 Pathway
REACT_264273VEGFR2 mediated cell proliferation
  logo