MGP Database

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MGP000481

Record overview

MGPD IDMGP000481
Gene ID990
SpeciesHomo sapiens (Human)
Gene Namecell division cycle 6
Gene Symbol CDC6
SynonymsCDC18L; HsCDC6; HsCDC18;
Alternate namescell division control protein 6 homolog; p62(cdc6); CDC6-related protein; cdc18-related protein; cell division cycle 6 homolog; CDC6 cell division cycle 6 homolog;
Chromosome17
Map Location17q21.3
SummaryThe protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cyle is regulated through its phosphorylation by Cdks. Transcription of this protein was reported to be regulated in response to mitogenic signals through transcriptional control mechanism involving E2F proteins. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for CDC6

Proteins

cell division control protein 6 homolog
Refseq ID:NP_001245
Protein GI:4502703
UniProt ID:Q99741
mRNA ID:NM_001254
Length:560
RefSeq Status:
MPQTRSQAQATISFPKRKLSRALNKAKNSSDAKLEPTNVQTVTCSPRVKALPLSPRKRLGDDNLCNTPHLPPCSPPKQGKKENGPPHSHTLKGRRLVFDN
QLTIKSPSKRELAKVHQNKILSSVRKSQEITTNSEQRCPLKKESACVRLFKQEGTCYQQAKLVLNTAVPDRLPAREREMDVIRNFLREHICGKKAGSLYL
SGAPGTGKTACLSRILQDLKKELKGFKTIMLNCMSLRTAQAVFPAIAQEICQEEVSRPAGKDMMRKLEKHMTAEKGPMIVLVLDEMDQLDSKGQDVLYTL
FEWPWLSNSHLVLIGIANTLDLTDRILPRLQAREKCKPQLLNFPPYTRNQIVTILQDRLNQVSRDQVLDNAAVQFCARKVSAVSGDVRKALDVCRRAIEI
VESDVKSQTILKPLSECKSPSEPLIPKRVGLIHISQVISEVDGNRMTLSQEGAQDSFPLQQKILVCSLMLLIRQLKIKEVTLGKLYEAYSKVCRKQQVAA
VDQSECLSLSGLLEARGILGLKRNKETRLTKVFFKIEEKEIEHALKDKALIGNILATGLP
 
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