MGP Database

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MGP000481

Ontology/Pathway Information

Entrez Gene ID990
Gene Namecell division cycle 6
Gene Symbol CDC6
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 IDA:HPACcytoplasm
GO:0005829 TAS:ReactomeCcytosol
GO:0005794 IDA:HPACGolgi apparatus
GO:0005654 TAS:ReactomeCnucleoplasm
GO:0005634 IDA:BHF-UCLCnucleus
GO:0051233 IDA:BHF-UCLCspindle midzone
GO:0000922 IDA:BHF-UCLCspindle pole
GO:0005524 IEA:UniProtKB-KWFATP binding
GO:0003682 IEA:EnsemblFchromatin binding
GO:0019900 IPI:BHF-UCLFkinase binding
GO:0000166 TAS:ProtIncFnucleotide binding
GO:0006260 TAS:ReactomePDNA replication
GO:0000076 TAS:ProtIncPDNA replication checkpoint
GO:0000082 TAS:ReactomePG1/S transition of mitotic cell cycle
GO:0000278 TAS:ReactomePmitotic cell cycle
GO:0007067 IEA:UniProtKB-KWPmitotic nuclear division
GO:0008285 TAS:ProtIncPnegative regulation of cell proliferation
GO:0008156 TAS:ProtIncPnegative regulation of DNA replication
GO:0051984 IDA:BHF-UCLPpositive regulation of chromosome segregation
GO:0032467 IMP:BHF-UCLPpositive regulation of cytokinesis
GO:0000079 TAS:ProtIncPregulation of cyclin-dependent protein serine/threonine kinase activity
GO:0030071 IMP:BHF-UCLPregulation of mitotic metaphase/anaphase transition
GO:0000083 TAS:ReactomePregulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0007089 TAS:ProtIncPtraversing start control point of mitotic cell cycle
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_6769Activation of ATR in response to replication stress
REACT_1095Activation of the pre-replicative complex
REACT_2243Assembly of the pre-replicative complex
REACT_1181Association of licensing factors with the pre-replicative complex
REACT_1707CDC6 association with the ORC:origin complex
REACT_1221CDK-mediated phosphorylation and removal of Cdc6
REACT_1949CDT1 association with the CDC6:ORC:origin complex
REACT_115566Cell Cycle
REACT_1538Cell Cycle Checkpoints
REACT_152Cell Cycle, Mitotic
REACT_383DNA Replication
REACT_734DNA Replication Pre-Initiation
REACT_471E2F mediated regulation of DNA replication
REACT_111214G0 and Early G1
REACT_683G1/S-Specific Transcription
REACT_1783G1/S Transition
REACT_828G2/M Checkpoints
REACT_1725M/G1 Transition
REACT_21267Mitotic G1-G1/S phases
REACT_1156Orc1 removal from chromatin
REACT_829Regulation of DNA replication
REACT_207Removal of licensing factors from origins
REACT_899S Phase
REACT_2148Switching of origins to a post-replicative state
REACT_2014Synthesis of DNA
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