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MGP000482

Ontology/Pathway Information

Entrez Gene ID991
Gene Namecell division cycle 20
Gene Symbol CDC20
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005813 IEA:EnsemblCcentrosome
GO:0005737 IDA:HPACcytoplasm
GO:0005829 TAS:ReactomeCcytosol
GO:0005654 TAS:ReactomeCnucleoplasm
GO:0005634 IDA:HPACnucleus
GO:0048471 IEA:EnsemblCperinuclear region of cytoplasm
GO:0043234 IEA:EnsemblCprotein complex
GO:0005819 TAS:ProtIncCspindle
GO:0000922 IEA:UniProtKB-SubCellCspindle pole
GO:0019899 IPI:UniProtKBFenzyme binding
GO:0008022 IPI:UniProtKBFprotein C-terminus binding
GO:0051488 IDA:UniProtKBPactivation of anaphase-promoting complex activity
GO:0031145 IDA:UniProtKBPanaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0007049 TAS:ProtIncPcell cycle
GO:0000278 TAS:ReactomePmitotic cell cycle
GO:0007067 IEA:UniProtKB-KWPmitotic nuclear division
GO:0007094 TAS:ReactomePmitotic spindle assembly checkpoint
GO:0051436 TAS:ReactomePnegative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0008284 IEA:EnsemblPpositive regulation of cell proliferation
GO:0090129 ISS:UniProtKBPpositive regulation of synapse maturation
GO:0031915 ISS:UniProtKBPpositive regulation of synaptic plasticity
GO:0051437 TAS:ReactomePpositive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0016567 IEA:UniProtKB-UniPathwayPprotein ubiquitination
GO:0050773 IEA:EnsemblPregulation of dendrite development
GO:0040020 IEA:EnsemblPregulation of meiosis
GO:0051439 TAS:ReactomePregulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_6954Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
REACT_75774Adaptive Immune System
REACT_75842Antigen processing: Ubiquitination & Proteasome degradation
REACT_6820APC/C:Cdc20 mediated degradation of Cyclin B
REACT_6781APC/C:Cdc20 mediated degradation of mitotic proteins
REACT_6871APC/C:Cdc20 mediated degradation of Securin
REACT_6761APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
REACT_267701APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
REACT_8017APC-Cdc20 mediated degradation of Nek2A
REACT_6828APC/C-mediated degradation of cell cycle proteins
REACT_6850Cdc20:Phospho-APC/C mediated degradation of Cyclin A
REACT_115566Cell Cycle
REACT_1538Cell Cycle Checkpoints
REACT_152Cell Cycle, Mitotic
REACT_75820Class I MHC mediated antigen processing & presentation
REACT_6867Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
REACT_6900Immune System
REACT_1072Inactivation of APC/C via direct inhibition of the APC/C complex
REACT_1041Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
REACT_1275Mitotic Anaphase
REACT_150314Mitotic Metaphase and Anaphase
REACT_682Mitotic Prometaphase
REACT_2137Mitotic Spindle Checkpoint
REACT_910M Phase
REACT_6875Phosphorylation of Emi1
REACT_6837Regulation of APC/C activators between G1/S and early anaphase
REACT_21279Regulation of mitotic cell cycle
REACT_150425Resolution of Sister Chromatid Cohesion
REACT_6821SCF-beta-TrCP mediated degradation of Emi1
REACT_150471Separation of Sister Chromatids
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