MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP000505

Record overview

MGPD IDMGP000505
Gene ID1017
SpeciesHomo sapiens (Human)
Gene Namecyclin-dependent kinase 2
Gene Symbol CDK2
SynonymsCDKN2; p33(CDK2);
Alternate namescyclin-dependent kinase 2; p33 protein kinase; cdc2-related protein kinase; cell division protein kinase 2;
Chromosome12
Map Location12q13
EC Number2.7.11.22
SummaryThis gene encodes a member of a family of serine/threonine protein kinases that participate in cell cycle regulation. The encoded protein is the catalytic subunit of the cyclin-dependent protein kinase complex, which regulates progression through the cell cycle. Activity of this protein is especially critical during the G1 to S phase transition. This protein associates with and regulated by other subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A), and p27Kip1 (CDKN1B). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
OrthologsView orthologs and multiple alignments for CDK2

Proteins

cyclin-dependent kinase 2 isoform 1
Refseq ID:NP_001789
Protein GI:16936528
UniProt ID:P24941
mRNA ID:NM_001798
Length:298
RefSeq Status:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIP
LPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRR
ALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
 
cyclin-dependent kinase 2 isoform 2
Refseq ID:NP_439892
Protein GI:166362719
UniProt ID:P24941
mRNA ID:NM_052827
Length:264
RefSeq Status:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIP
LPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMP
DYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
 
cyclin-dependent kinase 2 isoform 3
Refseq ID:NP_001277159
Protein GI:589811557
UniProt ID:P24941
mRNA ID:NM_001290230
Length:238
RefSeq Status:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHR
DLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGR
SLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
 
  logo