MGP Database

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MGP000505

Ontology/Pathway Information

Entrez Gene ID1017
Gene Namecyclin-dependent kinase 2
Gene Symbol CDK2
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0015030 IDA:UniProtKBCCajal body
GO:0005813 TAS:UniProtKBCcentrosome
GO:0000781 IEA:EnsemblCchromosome, telomeric region
GO:0000793 IEA:EnsemblCcondensed chromosome
GO:0000307 IDA:UniProtKBCcyclin-dependent protein kinase holoenzyme complex
GO:0005737 IDA:UniProtKBCcytoplasm
GO:0005829 TAS:ReactomeCcytosol
GO:0005768 IDA:UniProtKBCendosome
GO:0005654 TAS:ReactomeCnucleoplasm
GO:0005634 IDA:UniProtKBCnucleus
GO:0005667 IEA:EnsemblCtranscription factor complex
GO:0000805 IEA:EnsemblCX chromosome
GO:0000806 IEA:EnsemblCY chromosome
GO:0005524 IEA:UniProtKB-KWFATP binding
GO:0030332 IDA:UniProtKBFcyclin binding
GO:0004693 IDA:UniProtKBFcyclin-dependent protein serine/threonine kinase activity
GO:0046872 IEA:UniProtKB-KWFmetal ion binding
GO:0031145 TAS:ReactomePanaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0007596 TAS:ReactomePblood coagulation
GO:0071732 TAS:UniProtKBPcellular response to nitric oxide
GO:0051298 TAS:UniProtKBPcentrosome duplication
GO:0006977 TAS:ReactomePDNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0006281 IEA:UniProtKB-KWPDNA repair
GO:0006260 TAS:UniProtKBPDNA replication
GO:0000082 TAS:ReactomePG1/S transition of mitotic cell cycle
GO:0000086 NAS:UniProtKBPG2/M transition of mitotic cell cycle
GO:0016572 IDA:GOCPhistone phosphorylation
GO:0007126 TAS:UniProtKBPmeiotic nuclear division
GO:0000278 TAS:ReactomePmitotic cell cycle
GO:0031571 TAS:UniProtKBPmitotic G1 DNA damage checkpoint
GO:0007067 IEA:UniProtKB-KWPmitotic nuclear division
GO:0008284 IDA:UniProtKBPpositive regulation of cell proliferation
GO:0032298 IEA:EnsemblPpositive regulation of DNA-dependent DNA replication initiation
GO:0045893 IEA:EnsemblPpositive regulation of transcription, DNA-templated
GO:0006813 IEA:EnsemblPpotassium ion transport
GO:0007265 IEP:BHF-UCLPRas protein signal transduction
GO:0060968 IDA:UniProtKBPregulation of gene silencing
GO:0051439 TAS:ReactomePregulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_6769Activation of ATR in response to replication stress
REACT_1095Activation of the pre-replicative complex
REACT_6828APC/C-mediated degradation of cell cycle proteins
REACT_1221CDK-mediated phosphorylation and removal of Cdc6
REACT_115566Cell Cycle
REACT_1538Cell Cycle Checkpoints
REACT_152Cell Cycle, Mitotic
REACT_120956Cellular responses to stress
REACT_169274Cellular Senescence
REACT_1857Cyclin A/B1 associated events during G2/M transition
REACT_9029Cyclin A:Cdk2-associated events at S phase entry
REACT_1574Cyclin E associated events during G1/S transition
REACT_169185DNA Damage/Telomere Stress Induced Senescence
REACT_383DNA Replication
REACT_734DNA Replication Pre-Initiation
REACT_24970Factors involved in megakaryocyte development and platelet production
REACT_111214G0 and Early G1
REACT_2254G1/S DNA Damage Checkpoints
REACT_1783G1/S Transition
REACT_828G2/M Checkpoints
REACT_2203G2/M Transition
REACT_1915G2 Phase
REACT_604Hemostasis
REACT_111183Meiosis
REACT_27271Meiotic recombination
REACT_1725M/G1 Transition
REACT_21267Mitotic G1-G1/S phases
REACT_21391Mitotic G2-G2/M phases
REACT_1156Orc1 removal from chromatin
REACT_1625p53-Dependent G1 DNA Damage Response
REACT_85p53-Dependent G1/S DNA damage checkpoint
REACT_308Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes
REACT_6837Regulation of APC/C activators between G1/S and early anaphase
REACT_829Regulation of DNA replication
REACT_21279Regulation of mitotic cell cycle
REACT_207Removal of licensing factors from origins
REACT_9003SCF(Skp2)-mediated degradation of p27/p21
REACT_169168Senescence-Associated Secretory Phenotype (SASP)
REACT_899S Phase
REACT_2148Switching of origins to a post-replicative state
REACT_2014Synthesis of DNA
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