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MGP000508

Record overview

MGPD IDMGP000508
Gene ID1021
SpeciesHomo sapiens (Human)
Gene Namecyclin-dependent kinase 6
Gene Symbol CDK6
SynonymsMCPH12; PLSTIRE;
Alternate namescyclin-dependent kinase 6; cell division protein kinase 6; serine/threonine-protein kinase PLSTIRE;
Chromosome7
Map Location7q21-q22
EC Number2.7.11.22
SummaryThe protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. Expression of this gene is up-regulated in some types of cancer. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2009]
OrthologsView orthologs and multiple alignments for CDK6

Proteins

cyclin-dependent kinase 6
Refseq ID:NP_001138778
Protein GI:223718134
UniProt ID:Q00534
mRNA ID:NM_001145306
Length:326
RefSeq Status:
MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEH
VDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPV
DLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF
QDLERCKENLDSHLPPSQNTSELNTA
 
cyclin-dependent kinase 6
Refseq ID:NP_001250
Protein GI:4502741
UniProt ID:Q00534
mRNA ID:NM_001259
Length:326
RefSeq Status:
Protein sequence is identical to GI:223718134 (mRNA isoform)
 
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