MGP Database

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MGP000508

Ontology/Pathway Information

Entrez Gene ID1021
Gene Namecyclin-dependent kinase 6
Gene Symbol CDK6
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0000307 IDA:BHF-UCLCcyclin-dependent protein kinase holoenzyme complex
GO:0005737 IDA:BHF-UCLCcytoplasm
GO:0005829 TAS:ReactomeCcytosol
GO:0005634 IDA:BHF-UCLCnucleus
GO:0001726 IDA:BHF-UCLCruffle
GO:0005524 IDA:BHF-UCLFATP binding
GO:0030332 IPI:BHF-UCLFcyclin binding
GO:0004693 IDA:BHF-UCLFcyclin-dependent protein serine/threonine kinase activity
GO:0014002 ISS:UniProtKBPastrocyte development
GO:0007050 TAS:UniProtKBPcell cycle arrest
GO:0043697 IMP:BHF-UCLPcell dedifferentiation
GO:0051301 IEA:UniProtKB-KWPcell division
GO:0021542 ISS:UniProtKBPdentate gyrus development
GO:0000082 TAS:UniProtKBPG1/S transition of mitotic cell cycle
GO:0048699 ISS:UniProtKBPgeneration of neurons
GO:0042063 IMP:BHF-UCLPgliogenesis
GO:0021670 ISS:UniProtKBPlateral ventricle development
GO:0000278 TAS:ReactomePmitotic cell cycle
GO:0045786 IDA:UniProtKBPnegative regulation of cell cycle
GO:0045596 TAS:UniProtKBPnegative regulation of cell differentiation
GO:0008285 TAS:UniProtKBPnegative regulation of cell proliferation
GO:2000773 IDA:UniProtKBPnegative regulation of cellular senescence
GO:0050680 IMP:BHF-UCLPnegative regulation of epithelial cell proliferation
GO:0045638 IDA:UniProtKBPnegative regulation of myeloid cell differentiation
GO:0045668 IDA:BHF-UCLPnegative regulation of osteoblast differentiation
GO:0001954 IDA:BHF-UCLPpositive regulation of cell-matrix adhesion
GO:0048146 IMP:BHF-UCLPpositive regulation of fibroblast proliferation
GO:0006468 IDA:BHF-UCLPprotein phosphorylation
GO:2000145 ISS:UniProtKBPregulation of cell motility
GO:0045646 IMP:BHF-UCLPregulation of erythrocyte differentiation
GO:0010468 IDA:BHF-UCLPregulation of gene expression
GO:0009615 IEP:UniProtKBPresponse to virus
GO:0003323 IDA:UniProtKBPtype B pancreatic cell development
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_115566Cell Cycle
REACT_152Cell Cycle, Mitotic
REACT_120956Cellular responses to stress
REACT_169274Cellular Senescence
REACT_821Cyclin D associated events in G1
REACT_1590G1 Phase
REACT_21267Mitotic G1-G1/S phases
REACT_169325Oncogene Induced Senescence
REACT_169436Oxidative Stress Induced Senescence
REACT_169168Senescence-Associated Secretory Phenotype (SASP)
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