MGP Database

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MGP000512

Ontology/Pathway Information

Entrez Gene ID1026
Gene Namecyclin-dependent kinase inhibitor 1A (p21, Cip1)
Gene Symbol CDKN1A
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0000307 IDA:BHF-UCLCcyclin-dependent protein kinase holoenzyme complex
GO:0005829 TAS:ReactomeCcytosol
GO:0043231 IDA:HPACintracellular membrane-bounded organelle
GO:0005654 TAS:ReactomeCnucleoplasm
GO:0005634 IDA:BHF-UCLCnucleus
GO:0070557 IDA:UniProtKBCPCNA-p21 complex
GO:0048471 IEA:EnsemblCperinuclear region of cytoplasm
GO:0019912 IDA:UniProtKBFcyclin-dependent protein kinase activating kinase activity
GO:0004861 TAS:BHF-UCLFcyclin-dependent protein serine/threonine kinase inhibitor activity
GO:0046872 IEA:UniProtKB-KWFmetal ion binding
GO:0031625 IPI:UniProtKBFubiquitin protein ligase binding
GO:0007050 IDA:BHF-UCLPcell cycle arrest
GO:0006974 IMP:BHF-UCLPcellular response to DNA damage stimulus
GO:0031668 IMP:BHF-UCLPcellular response to extracellular stimulus
GO:0034605 IEA:EnsemblPcellular response to heat
GO:0071479 IMP:BHF-UCLPcellular response to ionizing radiation
GO:0090398 IMP:BHF-UCLPcellular senescence
GO:0006977 IDA:BHF-UCLPDNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0007173 TAS:ReactomePepidermal growth factor receptor signaling pathway
GO:0038095 TAS:ReactomePFc-epsilon receptor signaling pathway
GO:0008543 TAS:ReactomePfibroblast growth factor receptor signaling pathway
GO:0000082 IDA:BHF-UCLPG1/S transition of mitotic cell cycle
GO:0000086 IMP:BHF-UCLPG2/M transition of mitotic cell cycle
GO:0045087 TAS:ReactomePinnate immune response
GO:0060574 IEA:EnsemblPintestinal epithelial cell maturation
GO:0097193 TAS:ProtIncPintrinsic apoptotic signaling pathway
GO:0042771 IEA:EnsemblPintrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0000278 TAS:ReactomePmitotic cell cycle
GO:0071850 IEA:EnsemblPmitotic cell cycle arrest
GO:0043066 IEA:EnsemblPnegative regulation of apoptotic process
GO:0030308 IDA:BHF-UCLPnegative regulation of cell growth
GO:0008285 IDA:BHF-UCLPnegative regulation of cell proliferation
GO:0045736 IEA:EnsemblPnegative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0010629 IEA:EnsemblPnegative regulation of gene expression
GO:0042326 IDA:BHF-UCLPnegative regulation of phosphorylation
GO:0048011 TAS:ReactomePneurotrophin TRK receptor signaling pathway
GO:0031100 IEA:EnsemblPorgan regeneration
GO:0048015 TAS:ReactomePphosphatidylinositol-mediated signaling
GO:0030890 IEA:EnsemblPpositive regulation of B cell proliferation
GO:0048146 IMP:BHF-UCLPpositive regulation of fibroblast proliferation
GO:0043068 IEA:EnsemblPpositive regulation of programmed cell death
GO:0045860 IDA:GOCPpositive regulation of protein kinase activity
GO:2000379 IMP:BHF-UCLPpositive regulation of reactive oxygen species metabolic process
GO:0006468 IDA:GOCPprotein phosphorylation
GO:0007265 IEP:BHF-UCLPRas protein signal transduction
GO:0000079 TAS:ProtIncPregulation of cyclin-dependent protein serine/threonine kinase activity
GO:2000278 IEA:EnsemblPregulation of DNA biosynthetic process
GO:0033158 IEA:EnsemblPregulation of protein import into nucleus, translocation
GO:0046685 IEA:EnsemblPresponse to arsenic-containing substance
GO:0051412 IEA:EnsemblPresponse to corticosterone
GO:0042493 IEA:EnsemblPresponse to drug
GO:0055093 IEA:EnsemblPresponse to hyperoxia
GO:0010243 IEA:EnsemblPresponse to organonitrogen compound
GO:0009636 IEA:EnsemblPresponse to toxic substance
GO:0009411 IEA:EnsemblPresponse to UV
GO:0010165 IEA:EnsemblPresponse to X-ray
GO:0090400 TAS:BHF-UCLPstress-induced premature senescence
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_75774Adaptive Immune System
REACT_12564AKT phosphorylates targets in the cytosol
REACT_115566Cell Cycle
REACT_1538Cell Cycle Checkpoints
REACT_152Cell Cycle, Mitotic
REACT_120956Cellular responses to stress
REACT_169274Cellular Senescence
REACT_147727Constitutive PI3K/AKT Signaling in Cancer
REACT_9029Cyclin A:Cdk2-associated events at S phase entry
REACT_821Cyclin D associated events in G1
REACT_1574Cyclin E associated events during G1/S transition
REACT_147694DAP12 interactions
REACT_147814DAP12 signaling
REACT_116125Disease
REACT_169185DNA Damage/Telomere Stress Induced Senescence
REACT_383DNA Replication
REACT_118638Downstream signaling events of B Cell Receptor (BCR)
REACT_21272Downstream signaling of activated FGFR
REACT_17025Downstream signal transduction
REACT_163936Fc epsilon receptor (FCERI) signaling
REACT_1590G1 Phase
REACT_2254G1/S DNA Damage Checkpoints
REACT_1783G1/S Transition
REACT_12578GAB1 signalosome
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_21267Mitotic G1-G1/S phases
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_1156Orc1 removal from chromatin
REACT_1625p53-Dependent G1 DNA Damage Response
REACT_85p53-Dependent G1/S DNA damage checkpoint
REACT_12464PI3K/AKT activation
REACT_147723PI3K/AKT Signaling in Cancer
REACT_21270PI-3K cascade
REACT_116008PI3K events in ERBB2 signaling
REACT_115961PI3K events in ERBB4 signaling
REACT_75829PIP3 activates AKT signaling
REACT_829Regulation of DNA replication
REACT_207Removal of licensing factors from origins
REACT_163769Role of LAT2/NTAL/LAB on calcium mobilization
REACT_9003SCF(Skp2)-mediated degradation of p27/p21
REACT_169168Senescence-Associated Secretory Phenotype (SASP)
REACT_9417Signaling by EGFR
REACT_115871Signaling by EGFR in Cancer
REACT_268269Signaling by EGFRvIII in Cancer
REACT_115755Signaling by ERBB2
REACT_115596Signaling by ERBB4
REACT_9470Signaling by FGFR
REACT_120736Signaling by FGFR in disease
REACT_268006Signaling by Ligand-Responsive EGFR Variants in Cancer
REACT_268546Signaling by Overexpressed Wild-Type EGFR in Cancer
REACT_16888Signaling by PDGF
REACT_111040Signaling by SCF-KIT
REACT_118773Signaling by the B Cell Receptor (BCR)
REACT_11061Signalling by NGF
REACT_111102Signal Transduction
REACT_899S Phase
REACT_2148Switching of origins to a post-replicative state
REACT_2014Synthesis of DNA
REACT_346Transcriptional activation of cell cycle inhibitor p21
REACT_202Transcriptional activation of p53 responsive genes
SMP Pathway Links
SMP IDDescription
SMP00436Vinblastine Action Pathway
SMP00437Vincristine Action Pathway
SMP00438Vindesine Action Pathway
SMP00439Vinorelbine Action Pathway
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