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MGP000513

Record overview

MGPD IDMGP000513
Gene ID1027
SpeciesHomo sapiens (Human)
Gene Namecyclin-dependent kinase inhibitor 1B (p27, Kip1)
Gene Symbol CDKN1B
SynonymsKIP1; MEN4; CDKN4; MEN1B; P27KIP1;
Alternate namescyclin-dependent kinase inhibitor 1B;
Chromosome12
Map Location12p13.1-p12
SummaryThis gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN4). [provided by RefSeq, Apr 2014]
OrthologsView orthologs and multiple alignments for CDKN1B

Proteins

cyclin-dependent kinase inhibitor 1B
Refseq ID:NP_004055
Protein GI:4757962
UniProt ID:P46527
mRNA ID:NM_004064
Length:198
RefSeq Status:
MSNVRVSNGSPSLERMDARQAEHPKPSACRNLFGPVDHEELTRDLEKHCRDMEEASQRKWNFDFQNHKPLEGKYEWQEVEKGSLPEFYYRPPRPPKGACK
VPAQESQDVSGSRPAAPLIGAPANSEDTHLVDPKTDPSDSQTGLAEQCAGIRKRPATDDSSTQNKRANRTEENVSDGSPNAGSVEQTPKKPGLRRRQT
 
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