MGP Database

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MGP000513

Ontology/Pathway Information

Entrez Gene ID1027
Gene Namecyclin-dependent kinase inhibitor 1B (p27, Kip1)
Gene Symbol CDKN1B
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 IDA:HGNCCcytoplasm
GO:0005829 TAS:ReactomeCcytosol
GO:0005768 IEA:UniProtKB-SubCellCendosome
GO:0005654 TAS:ReactomeCnucleoplasm
GO:0005634 IDA:BHF-UCLCnucleus
GO:0043234 IEA:EnsemblCprotein complex
GO:0004861 TAS:ProtIncFcyclin-dependent protein serine/threonine kinase inhibitor activity
GO:0019903 IPI:BHF-UCLFprotein phosphatase binding
GO:0005072 TAS:ProtIncFtransforming growth factor beta receptor, cytoplasmic mediator activity
GO:0006919 IDA:UniProtKBPactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0048102 IDA:BHF-UCLPautophagic cell death
GO:0007050 IMP:HGNCPcell cycle arrest
GO:0071236 IEA:EnsemblPcellular response to antibiotic
GO:0071285 IDA:MGIPcellular response to lithium ion
GO:0071407 IEA:EnsemblPcellular response to organic cyclic compound
GO:0006977 TAS:ReactomePDNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0007173 TAS:ReactomePepidermal growth factor receptor signaling pathway
GO:0038095 TAS:ReactomePFc-epsilon receptor signaling pathway
GO:0008543 TAS:ReactomePfibroblast growth factor receptor signaling pathway
GO:0000082 IDA:BHF-UCLPG1/S transition of mitotic cell cycle
GO:0045087 TAS:ReactomePinnate immune response
GO:0048839 IEA:EnsemblPinner ear development
GO:0000278 TAS:ReactomePmitotic cell cycle
GO:0071850 IDA:UniProtKBPmitotic cell cycle arrest
GO:0043066 IEA:EnsemblPnegative regulation of apoptotic process
GO:0030308 IDA:BHF-UCLPnegative regulation of cell growth
GO:0008285 IDA:UniProtKBPnegative regulation of cell proliferation
GO:0051271 IEA:EnsemblPnegative regulation of cellular component movement
GO:0045736 IEA:EnsemblPnegative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0060770 IEA:EnsemblPnegative regulation of epithelial cell proliferation involved in prostate gland development
GO:0033673 IDA:UniProtKBPnegative regulation of kinase activity
GO:0045930 IDA:UniProtKBPnegative regulation of mitotic cell cycle
GO:0042326 IDA:BHF-UCLPnegative regulation of phosphorylation
GO:0045892 IDA:UniProtKBPnegative regulation of transcription, DNA-templated
GO:0048011 TAS:ReactomePneurotrophin TRK receptor signaling pathway
GO:0048015 TAS:ReactomePphosphatidylinositol-mediated signaling
GO:0010942 IDA:UniProtKBPpositive regulation of cell death
GO:0008284 IEA:EnsemblPpositive regulation of cell proliferation
GO:0031116 IEA:EnsemblPpositive regulation of microtubule polymerization
GO:0045732 IDA:MGIPpositive regulation of protein catabolic process
GO:0006813 IEA:EnsemblPpotassium ion transport
GO:0000079 TAS:ProtIncPregulation of cyclin-dependent protein serine/threonine kinase activity
GO:0043200 IEA:EnsemblPresponse to amino acid
GO:0046686 IEA:EnsemblPresponse to cadmium ion
GO:0042493 IEA:EnsemblPresponse to drug
GO:0032355 IEA:EnsemblPresponse to estradiol
GO:0009749 IEA:EnsemblPresponse to glucose
GO:0001666 IEA:EnsemblPresponse to hypoxia
GO:0043434 IEA:EnsemblPresponse to peptide hormone
GO:0007605 IEA:EnsemblPsensory perception of sound
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_75774Adaptive Immune System
REACT_12564AKT phosphorylates targets in the cytosol
REACT_115566Cell Cycle
REACT_1538Cell Cycle Checkpoints
REACT_152Cell Cycle, Mitotic
REACT_120956Cellular responses to stress
REACT_169274Cellular Senescence
REACT_147727Constitutive PI3K/AKT Signaling in Cancer
REACT_9029Cyclin A:Cdk2-associated events at S phase entry
REACT_821Cyclin D associated events in G1
REACT_1574Cyclin E associated events during G1/S transition
REACT_147694DAP12 interactions
REACT_147814DAP12 signaling
REACT_116125Disease
REACT_169185DNA Damage/Telomere Stress Induced Senescence
REACT_383DNA Replication
REACT_118638Downstream signaling events of B Cell Receptor (BCR)
REACT_21272Downstream signaling of activated FGFR
REACT_17025Downstream signal transduction
REACT_163936Fc epsilon receptor (FCERI) signaling
REACT_1590G1 Phase
REACT_2254G1/S DNA Damage Checkpoints
REACT_1783G1/S Transition
REACT_12578GAB1 signalosome
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_21267Mitotic G1-G1/S phases
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_1156Orc1 removal from chromatin
REACT_1625p53-Dependent G1 DNA Damage Response
REACT_85p53-Dependent G1/S DNA damage checkpoint
REACT_12464PI3K/AKT activation
REACT_147723PI3K/AKT Signaling in Cancer
REACT_21270PI-3K cascade
REACT_116008PI3K events in ERBB2 signaling
REACT_115961PI3K events in ERBB4 signaling
REACT_75829PIP3 activates AKT signaling
REACT_829Regulation of DNA replication
REACT_207Removal of licensing factors from origins
REACT_163769Role of LAT2/NTAL/LAB on calcium mobilization
REACT_9003SCF(Skp2)-mediated degradation of p27/p21
REACT_169168Senescence-Associated Secretory Phenotype (SASP)
REACT_9417Signaling by EGFR
REACT_115871Signaling by EGFR in Cancer
REACT_268269Signaling by EGFRvIII in Cancer
REACT_115755Signaling by ERBB2
REACT_115596Signaling by ERBB4
REACT_9470Signaling by FGFR
REACT_120736Signaling by FGFR in disease
REACT_268006Signaling by Ligand-Responsive EGFR Variants in Cancer
REACT_268546Signaling by Overexpressed Wild-Type EGFR in Cancer
REACT_16888Signaling by PDGF
REACT_111040Signaling by SCF-KIT
REACT_118773Signaling by the B Cell Receptor (BCR)
REACT_11061Signalling by NGF
REACT_111102Signal Transduction
REACT_899S Phase
REACT_2148Switching of origins to a post-replicative state
REACT_2014Synthesis of DNA
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