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MGP000522

UniProt Annotations

Entry Information
Gene NameCCAAT/enhancer binding protein (C/EBP), beta
Protein EntryCEBPB_HUMAN
UniProt IDP17676
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative initiation; Named isoforms=3; Name=1; Synonyms=C/EBPbeta-FL; IsoId=P17676-1; Sequence=Displayed; Name=2; Synonyms=C/EBPbeta-LAP; IsoId=P17676-2; Sequence=VSP_053314; Name=3; Synonyms=C/EBPbeta-LIP; IsoId=P17676-3; Sequence=VSP_053313;
Domainthe 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors. {ECO:0000269|PubMed:17467953}.
FunctionImportant transcription factor regulating the expression of genes involved in immune and inflammatory responses. Binds to regulatory regions of several acute-phase and cytokines genes and probably plays a role in the regulation of acute-phase reaction, inflammation and hemopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Plays an important role in adipose tissue differentiation. Regulates the transcriptional induction of peroxisome proliferator-activated receptor gamma (PPARG) as well as other adipogenesis key player genes. {ECO:0000269|PubMed:20829347}.
FunctionIsoform 3: acts as a dominant negative through heterodimerization with isoform 2. {ECO:0000269|PubMed:20829347}.
InductionBy ER stress. {ECO:0000269|PubMed:20829347}.
InteractionQ86X55:CARM1; NbExp=2; IntAct=EBI-969696, EBI-2339854; P03120:E2 (xeno); NbExp=2; IntAct=EBI-969696, EBI-1779322; P03122:E2 (xeno); NbExp=3; IntAct=EBI-969696, EBI-7028618; P06422:E2 (xeno); NbExp=4; IntAct=EBI-969696, EBI-7136851; P06790:E2 (xeno); NbExp=4; IntAct=EBI-969696, EBI-7010629; P04637:TP53; NbExp=4; IntAct=EBI-969696, EBI-366083;
PtmPhosphorylated at Thr-235 by RPS6KA1. {ECO:0000269|PubMed:11684016}.
PtmSumoylated by polymeric chains of SUMO2 or SUMO3. {ECO:0000269|PubMed:12810706}.
SimilarityBelongs to the bZIP family. C/EBP subfamily. {ECO:0000305}.
SimilarityContains 1 bZIP (basic-leucine zipper) domain. {ECO:0000255|PROSITE-ProRule:PRU00978}.
Subcellular LocationNucleus {ECO:0000255|PROSITE- ProRule:PRU00978, ECO:0000269|PubMed:20829347}.
SubunitBinds DNA as a dimer and can form stable heterodimers with CEBPA, CEBPD and CEBPG. Isoform 2 and isoform 3 also form heterodimers. Interacts with TRIM28 and PTGES2. Interacts with PRDM16. Interacts with CCDC85B. Forms a complex with THOC5. Interacts with ZNF638; this interaction increases transcriptional activation. Interacts with CIDEA and CIDEC; these interactions increase transcriptional activation of a subset of CEBPB downstream target genes. Interacts with DDIT3/CHOP.Interacts with EP300; recruits EP300 to chromatin. Interacts with RORA; the interaction disrupts interaction with EP300. {ECO:0000269|PubMed:11257229, ECO:0000269|PubMed:11792321, ECO:0000269|PubMed:20829347}.
Tissue SpecificityExpressed at low levels in the lung, kidney and spleen.
Web ResourceName=SeattleSNPs; URL="http://pga.gs.washington.edu/data/cebpb/";
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