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MGP000541

Record overview

MGPD IDMGP000541
Gene ID1109
SpeciesHomo sapiens (Human)
Gene Namealdo-keto reductase family 1, member C4
Gene Symbol AKR1C4
SynonymsC11; CDR; DD4; CHDR; DD-4; HAKRA; 3-alpha-HSD;
Alternate namesaldo-keto reductase family 1 member C4; 3-alpha-HSD1; chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4; dihydrodiol dehydrogenase isozyme DD4; type I 3-alpha-hydroxysteroid dehydrogenase;
Chromosome10
Map Location10p15.1
EC Number1.1.1.-
SummaryThis gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the bioreduction of chlordecone, a toxic organochlorine pesticide, to chlordecone alcohol in liver. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for AKR1C4

Proteins

aldo-keto reductase family 1 member C4
Refseq ID:NP_001809
Protein GI:325652083
UniProt ID:P17516
mRNA ID:NM_001818
Length:323
RefSeq Status:
MDPKYQRVELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALE
SSLKKLQLDYVDLYLLHFPMALKPGETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKPGLKYKPVCNQVECHPYLNQS
KLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLN
RNYRYVVMDFLMDHPDYPFSDEY
 
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