MGP Database

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MGP000541

Ontology/Pathway Information

Entrez Gene ID1109
Gene Namealdo-keto reductase family 1, member C4
Gene Symbol AKR1C4
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 TAS:ProtIncCcytoplasm
GO:0005829 TAS:ReactomeCcytosol
GO:0070062 IDA:UniProtKBCextracellular vesicular exosome
GO:0004033 TAS:ProtIncFaldo-keto reductase (NADP) activity
GO:0047023 IDA:UniProtKBFandrosterone dehydrogenase activity
GO:0015125 TAS:ProtIncFbile acid transmembrane transporter activity
GO:0047743 IEA:UniProtKB-ECFchlordecone reductase activity
GO:0009055 TAS:UniProtKBFelectron carrier activity
GO:0016655 IDA:UniProtKBFoxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
GO:0001758 IDA:UniProtKBFretinal dehydrogenase activity
GO:0008209 TAS:ProtIncPandrogen metabolic process
GO:0015721 TAS:ProtIncPbile acid and bile salt transport
GO:0006699 TAS:ReactomePbile acid biosynthetic process
GO:0008206 TAS:ReactomePbile acid metabolic process
GO:0071395 IDA:UniProtKBPcellular response to jasmonic acid stimulus
GO:0044597 IMP:UniProtKBPdaunorubicin metabolic process
GO:0044598 IMP:UniProtKBPdoxorubicin metabolic process
GO:0007603 TAS:ReactomePphototransduction, visible light
GO:0001523 TAS:ReactomePretinoid metabolic process
GO:0044281 TAS:ReactomePsmall molecule metabolic process
GO:0008202 TAS:ProtIncPsteroid metabolic process
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_11040Bile acid and bile salt metabolism
REACT_116125Disease
REACT_160102Diseases associated with visual transduction
REACT_111217Metabolism
REACT_22258Metabolism of lipids and lipoproteins
REACT_24968Retinoid metabolism and transport
REACT_111102Signal Transduction
REACT_11054Synthesis of bile acids and bile salts
REACT_11053Synthesis of bile acids and bile salts via 24-hydroxycholesterol
REACT_11048Synthesis of bile acids and bile salts via 27-hydroxycholesterol
REACT_11041Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
REACT_160125Visual phototransduction
SMP Pathway Links
SMP IDDescription
SMP0057511-beta-hydroxylase deficiency (CYP11B1)
SMP0056617-alpha-hydroxylase deficiency (CYP17)
SMP0057621-hydroxylase deficiency (CYP21)
SMP0072027-Hydroxylase Deficiency
SMP007183-Beta-Hydroxysteroid Dehydrogenase Deficiency
SMP00373Adrenal Hyperplasia Type 3 or Congenital Adrenal Hyperplasia due to 21-hydroxylase Deficiency
SMP00372Adrenal Hyperplasia Type 5 or Congenital Adrenal Hyperplasia due to 17 Alpha-hydroxylase Deficiency
SMP00717Apparent mineralocorticoid excess syndrome
SMP00035Bile Acid Biosynthesis
SMP00315Cerebrotendinous Xanthomatosis (CTX)
SMP00314Congenital Bile Acid Synthesis Defect Type II
SMP00318Congenital Bile Acid Synthesis Defect Type III
SMP00371Congenital Lipoid Adrenal Hyperplasia (CLAH) or Lipoid CAH
SMP00577Corticosterone methyl oxidase I deficiency (CMO I)
SMP00578Corticosterone methyl oxidase II deficiency - CMO II
SMP00317Familial Hypercholanemia (FHCA)
SMP00130Steroidogenesis
SMP00316Zellweger Syndrome
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