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MGP000542

Record overview

MGPD IDMGP000542
Gene ID1111
SpeciesHomo sapiens (Human)
Gene Namecheckpoint kinase 1
Gene Symbol CHEK1
SynonymsCHK1;
Alternate namesserine/threonine-protein kinase Chk1; Chk1-S; checkpoint kinase-1; CHK1 checkpoint homolog; cell cycle checkpoint kinase; Checkpoint, S. pombe, homolog of, 1;
Chromosome11
Map Location11q24.2
EC Number2.7.11.1
SummaryThe protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2011]
OrthologsView orthologs and multiple alignments for CHEK1

Proteins

serine/threonine-protein kinase Chk1 isoform 1
Refseq ID:NP_001265
Protein GI:166295192
UniProt ID:O14757
mRNA ID:NM_001274
Length:476
RefSeq Status:
MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINKMLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDI
GMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTA
MLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDF
SPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLLGTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKL
GYQWKKSCMNQVTISTTDRRNNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT
 
serine/threonine-protein kinase Chk1 isoform 1
Refseq ID:NP_001107593
Protein GI:166295194
UniProt ID:O14757
mRNA ID:NM_001114121
Length:476
RefSeq Status:
Protein sequence is identical to GI:166295192 (mRNA isoform)
 
serine/threonine-protein kinase Chk1 isoform 1
Refseq ID:NP_001107594
Protein GI:166295196
UniProt ID:O14757
mRNA ID:NM_001114122
Length:476
RefSeq Status:
Protein sequence is identical to GI:166295192 (mRNA isoform)
 
serine/threonine-protein kinase Chk1 isoform 2
Refseq ID:NP_001231775
Protein GI:349501061
UniProt ID:O14757
mRNA ID:NM_001244846
Length:442
RefSeq Status:
MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINKMLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDI
GMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTA
MLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDF
SPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLLGTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKL
GYQWKKSCMNQGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT
 
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