MGP Database

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MGP000542

Ontology/Pathway Information

Entrez Gene ID1111
Gene Namecheckpoint kinase 1
Gene Symbol CHEK1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005813 IDA:UniProtKBCcentrosome
GO:0000785 ISS:UniProtKBCchromatin
GO:0000794 IDA:UniProtKBCcondensed nuclear chromosome
GO:0005829 TAS:ReactomeCcytosol
GO:0005615 IDA:UniProtKBCextracellular space
GO:0043231 IDA:HPACintracellular membrane-bounded organelle
GO:0005654 TAS:ReactomeCnucleoplasm
GO:0005634 IDA:UniProtKBCnucleus
GO:0005657 IEA:EnsemblCreplication fork
GO:0005524 IEA:UniProtKB-KWFATP binding
GO:0035402 IDA:UniProtKBFhistone kinase activity (H3-T11 specific)
GO:0004674 IDA:UniProtKBFprotein serine/threonine kinase activity
GO:0071313 IEA:EnsemblPcellular response to caffeine
GO:0006974 IMP:UniProtKBPcellular response to DNA damage stimulus
GO:0071260 IEP:UniProtKBPcellular response to mechanical stimulus
GO:0048096 ISS:UniProtKBPchromatin-mediated maintenance of transcription
GO:0000077 IDA:UniProtKBPDNA damage checkpoint
GO:0006975 IDA:UniProtKBPDNA damage induced protein phosphorylation
GO:0006281 IMP:UniProtKBPDNA repair
GO:0006260 TAS:ReactomePDNA replication
GO:0031572 IMP:UniProtKBPG2 DNA damage checkpoint
GO:0000086 IEA:EnsemblPG2/M transition of mitotic cell cycle
GO:2000279 IEA:EnsemblPnegative regulation of DNA biosynthetic process
GO:0010972 IEA:EnsemblPnegative regulation of G2/M transition of mitotic cell cycle
GO:0045839 IDA:UniProtKBPnegative regulation of mitosis
GO:0018107 IDA:UniProtKBPpeptidyl-threonine phosphorylation
GO:0042127 IEA:EnsemblPregulation of cell proliferation
GO:0010569 IDA:UniProtKBPregulation of double-strand break repair via homologous recombination
GO:2000615 ISS:UniProtKBPregulation of histone H3-K9 acetylation
GO:0046602 IDA:UniProtKBPregulation of mitotic centrosome separation
GO:0010767 ISS:UniProtKBPregulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage
GO:0090399 NAS:BHF-UCLPreplicative senescence
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_6769Activation of ATR in response to replication stress
REACT_115566Cell Cycle
REACT_1538Cell Cycle Checkpoints
REACT_407Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
REACT_2254G1/S DNA Damage Checkpoints
REACT_828G2/M Checkpoints
REACT_897G2/M DNA damage checkpoint
REACT_2160p53-Independent DNA Damage Response
REACT_1208p53-Independent G1/S DNA damage checkpoint
REACT_111040Signaling by SCF-KIT
REACT_111102Signal Transduction
REACT_1614Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
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