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MGP000549

Record overview

MGPD IDMGP000549
Gene ID1129
SpeciesHomo sapiens (Human)
Gene Namecholinergic receptor, muscarinic 2
Gene Symbol CHRM2
SynonymsHM2;
Alternate namesmuscarinic acetylcholine receptor M2; 7TM receptor; muscarinic M2 receptor; acetylcholine receptor, muscarinic 2; cholinergic receptor, muscarinic 2, isoform a;
Chromosome7
Map Location7q31-q35
SummaryThe muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine to these receptors and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 2 is involved in mediation of bradycardia and a decrease in cardiac contractility. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for CHRM2

Proteins

muscarinic acetylcholine receptor M2
Refseq ID:NP_000730
Protein GI:4502817
UniProt ID:P08172
mRNA ID:NM_000739
Length:466
RefSeq Status:
MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWL
ALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVI
IMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDE
ITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITW
APYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
 
muscarinic acetylcholine receptor M2
Refseq ID:NP_001006632
Protein GI:54792115
UniProt ID:P08172
mRNA ID:NM_001006631
Length:466
RefSeq Status:
Protein sequence is identical to GI:4502817 (mRNA isoform)
 
muscarinic acetylcholine receptor M2
Refseq ID:NP_001006631
Protein GI:54792113
UniProt ID:P08172
mRNA ID:NM_001006630
Length:466
RefSeq Status:
Protein sequence is identical to GI:4502817 (mRNA isoform)
 
muscarinic acetylcholine receptor M2
Refseq ID:NP_001006630
Protein GI:54792111
UniProt ID:P08172
mRNA ID:NM_001006629
Length:466
RefSeq Status:
Protein sequence is identical to GI:4502817 (mRNA isoform)
 
muscarinic acetylcholine receptor M2
Refseq ID:NP_001006629
Protein GI:54792109
UniProt ID:P08172
mRNA ID:NM_001006628
Length:466
RefSeq Status:
Protein sequence is identical to GI:4502817 (mRNA isoform)
 
muscarinic acetylcholine receptor M2
Refseq ID:NP_001006628
Protein GI:54792107
UniProt ID:P08172
mRNA ID:NM_001006627
Length:466
RefSeq Status:
Protein sequence is identical to GI:4502817 (mRNA isoform)
 
muscarinic acetylcholine receptor M2
Refseq ID:NP_001006627
Protein GI:54792105
UniProt ID:P08172
mRNA ID:NM_001006626
Length:466
RefSeq Status:
Protein sequence is identical to GI:4502817 (mRNA isoform)
 
muscarinic acetylcholine receptor M2
Refseq ID:NP_001006633
Protein GI:54792117
UniProt ID:P08172
mRNA ID:NM_001006632
Length:466
RefSeq Status:
Protein sequence is identical to GI:4502817 (mRNA isoform)
 
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