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MGP000569

UniProt Annotations

Entry Information
Gene Namecreatine kinase, muscle
Protein EntryKCRM_HUMAN
UniProt IDP06732
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityATP + creatine = ADP + phosphocreatine. {ECO:0000255|PROSITE-ProRule:PRU10029}.
FunctionReversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.
SimilarityBelongs to the ATP:guanido phosphotransferase family. {ECO:0000255|PROSITE-ProRule:PRU00842, ECO:0000255|PROSITE- ProRule:PRU00843}.
SimilarityContains 1 phosphagen kinase C-terminal domain. {ECO:0000255|PROSITE-ProRule:PRU00843}.
SimilarityContains 1 phosphagen kinase N-terminal domain. {ECO:0000255|PROSITE-ProRule:PRU00842}.
Subcellular LocationCytoplasm.
SubunitDimer of identical or non-identical chains. With MM being the major form in skeletal muscle and myocardium, MB existing in myocardium, and BB existing in many tissues, especially brain.
Web ResourceName=SeattleSNPs; URL="http://pga.gs.washington.edu/data/ckm/";
Web ResourceName=Wikipedia; Note=CKM entry; URL="http://en.wikipedia.org/wiki/CKM_(gene)";
Web ResourceName=Wikipedia; Note=Creatine kinase entry; URL="http://en.wikipedia.org/wiki/Creatine_kinase";
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