MGP Database

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MGP000571

Record overview

MGPD IDMGP000571
Gene ID1160
SpeciesHomo sapiens (Human)
Gene Namecreatine kinase, mitochondrial 2 (sarcomeric)
Gene Symbol CKMT2
SynonymsSMTCK;
Alternate namescreatine kinase S-type, mitochondrial; S-MtCK; basic-type mitochondrial creatine kinase; mib-CK; sarcomeric mitochondrial creatine kinase;
Chromosome5
Map Location5q13.3
EC Number2.7.3.2
SummaryMitochondrial creatine kinase (MtCK) is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family. It exists as two isoenzymes, sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes. Mitochondrial creatine kinase occurs in two different oligomeric forms: dimers and octamers, in contrast to the exclusively dimeric cytosolic creatine kinase isoenzymes. Sarcomeric mitochondrial creatine kinase has 80% homology with the coding exons of ubiquitous mitochondrial creatine kinase. This gene contains sequences homologous to several motifs that are shared among some nuclear genes encoding mitochondrial proteins and thus may be essential for the coordinated activation of these genes during mitochondrial biogenesis. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for CKMT2

Proteins

creatine kinase S-type, mitochondrial precursor
Refseq ID:NP_001816
Protein GI:153251982
UniProt ID:P17540
mRNA ID:NM_001825
Length:419
RefSeq Status:
MASIFSKLLTGRNASLLFATMGTSVLTTGYLLNRQKVCAEVREQPRLFPPSADYPDLRKHNNCMAECLTPAIYAKLRNKVTPNGYTLDQCIQTGVDNPGH
PFIKTVGMVAGDEESYEVFADLFDPVIKLRHNGYDPRVMKHTTDLDASKITQGQFDEHYVLSSRVRTGRSIRGLSLPPACTRAERREVENVAITALEGLK
GDLAGRYYKLSEMTEQDQQRLIDDHFLFDKPVSPLLTCAGMARDWPDARGIWHNYDKTFLIWINEEDHTRVISMEKGGNMKRVFERFCRGLKEVERLIQE
RGWEFMWNERLGYILTCPSNLGTGLRAGVHVRIPKLSKDPRFSKILENLRLQKRGTGGVDTAAVADVYDISNIDRIGRSEVELVQIVIDGVNYLVDCEKK
LERGQDIKVPPPLPQFGKK
 
transit_peptide: 1..39
calculated_mol_wt: 4179
peptide sequence: 
MASIFSKLLTGRNASLLFATMGTSVLTTGYLLNRQKVCA

mat_peptide: 40..419
product: creatine kinase S-type, mitochondrial
calculated_mol_wt: 43344
peptide sequence: 
EVREQPRLFPPSADYPDLRKHNNCMAECLTPAIYAKLRNKVTPNGYTLDQCIQTGVDNPGHPFIKTVGMVAGDEESYEVFADLFDPVIKLRHNGYDPRVM
KHTTDLDASKITQGQFDEHYVLSSRVRTGRSIRGLSLPPACTRAERREVENVAITALEGLKGDLAGRYYKLSEMTEQDQQRLIDDHFLFDKPVSPLLTCA
GMARDWPDARGIWHNYDKTFLIWINEEDHTRVISMEKGGNMKRVFERFCRGLKEVERLIQERGWEFMWNERLGYILTCPSNLGTGLRAGVHVRIPKLSKD
PRFSKILENLRLQKRGTGGVDTAAVADVYDISNIDRIGRSEVELVQIVIDGVNYLVDCEKKLERGQDIKVPPPLPQFGKK

transit_peptide: 1..39
calculated_mol_wt: 4179
peptide sequence: 
MASIFSKLLTGRNASLLFATMGTSVLTTGYLLNRQKVCA

mat_peptide: 40..419
product: creatine kinase S-type, mitochondrial
calculated_mol_wt: 43344
peptide sequence: 
EVREQPRLFPPSADYPDLRKHNNCMAECLTPAIYAKLRNKVTPNGYTLDQCIQTGVDNPGHPFIKTVGMVAGDEESYEVFADLFDPVIKLRHNGYDPRVM
KHTTDLDASKITQGQFDEHYVLSSRVRTGRSIRGLSLPPACTRAERREVENVAITALEGLKGDLAGRYYKLSEMTEQDQQRLIDDHFLFDKPVSPLLTCA
GMARDWPDARGIWHNYDKTFLIWINEEDHTRVISMEKGGNMKRVFERFCRGLKEVERLIQERGWEFMWNERLGYILTCPSNLGTGLRAGVHVRIPKLSKD
PRFSKILENLRLQKRGTGGVDTAAVADVYDISNIDRIGRSEVELVQIVIDGVNYLVDCEKKLERGQDIKVPPPLPQFGKK

transit_peptide: 1..39
calculated_mol_wt: 4179
peptide sequence: 
MASIFSKLLTGRNASLLFATMGTSVLTTGYLLNRQKVCA

mat_peptide: 40..419
product: creatine kinase S-type, mitochondrial
calculated_mol_wt: 43344
peptide sequence: 
EVREQPRLFPPSADYPDLRKHNNCMAECLTPAIYAKLRNKVTPNGYTLDQCIQTGVDNPGHPFIKTVGMVAGDEESYEVFADLFDPVIKLRHNGYDPRVM
KHTTDLDASKITQGQFDEHYVLSSRVRTGRSIRGLSLPPACTRAERREVENVAITALEGLKGDLAGRYYKLSEMTEQDQQRLIDDHFLFDKPVSPLLTCA
GMARDWPDARGIWHNYDKTFLIWINEEDHTRVISMEKGGNMKRVFERFCRGLKEVERLIQERGWEFMWNERLGYILTCPSNLGTGLRAGVHVRIPKLSKD
PRFSKILENLRLQKRGTGGVDTAAVADVYDISNIDRIGRSEVELVQIVIDGVNYLVDCEKKLERGQDIKVPPPLPQFGKK
 
creatine kinase S-type, mitochondrial precursor
Refseq ID:NP_001093205
Protein GI:153251984
UniProt ID:P17540
mRNA ID:NM_001099735
Length:419
RefSeq Status:
Protein sequence is identical to GI:153251982 (mRNA isoform)
 
transit_peptide: 1..39
calculated_mol_wt: 4179
peptide sequence: 
MASIFSKLLTGRNASLLFATMGTSVLTTGYLLNRQKVCA

mat_peptide: 40..419
product: creatine kinase S-type, mitochondrial
calculated_mol_wt: 43344
peptide sequence: 
EVREQPRLFPPSADYPDLRKHNNCMAECLTPAIYAKLRNKVTPNGYTLDQCIQTGVDNPGHPFIKTVGMVAGDEESYEVFADLFDPVIKLRHNGYDPRVM
KHTTDLDASKITQGQFDEHYVLSSRVRTGRSIRGLSLPPACTRAERREVENVAITALEGLKGDLAGRYYKLSEMTEQDQQRLIDDHFLFDKPVSPLLTCA
GMARDWPDARGIWHNYDKTFLIWINEEDHTRVISMEKGGNMKRVFERFCRGLKEVERLIQERGWEFMWNERLGYILTCPSNLGTGLRAGVHVRIPKLSKD
PRFSKILENLRLQKRGTGGVDTAAVADVYDISNIDRIGRSEVELVQIVIDGVNYLVDCEKKLERGQDIKVPPPLPQFGKK
 
creatine kinase S-type, mitochondrial precursor
Refseq ID:NP_001093206
Protein GI:153252003
UniProt ID:P17540
mRNA ID:NM_001099736
Length:419
RefSeq Status:
Protein sequence is identical to GI:153251982 (mRNA isoform)
 
transit_peptide: 1..39
calculated_mol_wt: 4179
peptide sequence: 
MASIFSKLLTGRNASLLFATMGTSVLTTGYLLNRQKVCA

mat_peptide: 40..419
product: creatine kinase S-type, mitochondrial
calculated_mol_wt: 43344
peptide sequence: 
EVREQPRLFPPSADYPDLRKHNNCMAECLTPAIYAKLRNKVTPNGYTLDQCIQTGVDNPGHPFIKTVGMVAGDEESYEVFADLFDPVIKLRHNGYDPRVM
KHTTDLDASKITQGQFDEHYVLSSRVRTGRSIRGLSLPPACTRAERREVENVAITALEGLKGDLAGRYYKLSEMTEQDQQRLIDDHFLFDKPVSPLLTCA
GMARDWPDARGIWHNYDKTFLIWINEEDHTRVISMEKGGNMKRVFERFCRGLKEVERLIQERGWEFMWNERLGYILTCPSNLGTGLRAGVHVRIPKLSKD
PRFSKILENLRLQKRGTGGVDTAAVADVYDISNIDRIGRSEVELVQIVIDGVNYLVDCEKKLERGQDIKVPPPLPQFGKK

transit_peptide: 1..39
calculated_mol_wt: 4179
peptide sequence: 
MASIFSKLLTGRNASLLFATMGTSVLTTGYLLNRQKVCA

mat_peptide: 40..419
product: creatine kinase S-type, mitochondrial
calculated_mol_wt: 43344
peptide sequence: 
EVREQPRLFPPSADYPDLRKHNNCMAECLTPAIYAKLRNKVTPNGYTLDQCIQTGVDNPGHPFIKTVGMVAGDEESYEVFADLFDPVIKLRHNGYDPRVM
KHTTDLDASKITQGQFDEHYVLSSRVRTGRSIRGLSLPPACTRAERREVENVAITALEGLKGDLAGRYYKLSEMTEQDQQRLIDDHFLFDKPVSPLLTCA
GMARDWPDARGIWHNYDKTFLIWINEEDHTRVISMEKGGNMKRVFERFCRGLKEVERLIQERGWEFMWNERLGYILTCPSNLGTGLRAGVHVRIPKLSKD
PRFSKILENLRLQKRGTGGVDTAAVADVYDISNIDRIGRSEVELVQIVIDGVNYLVDCEKKLERGQDIKVPPPLPQFGKK
 
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