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MGP000571

UniProt Annotations

Entry Information
Gene Namecreatine kinase, mitochondrial 2 (sarcomeric)
Protein EntryKCRS_HUMAN
UniProt IDP17540
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityATP + creatine = ADP + phosphocreatine. {ECO:0000255|PROSITE-ProRule:PRU10029}.
FunctionReversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.
MiscellaneousMitochondrial creatine kinase binds cardiolipin.
SimilarityBelongs to the ATP:guanido phosphotransferase family. {ECO:0000255|PROSITE-ProRule:PRU00842, ECO:0000255|PROSITE- ProRule:PRU00843}.
SimilarityContains 1 phosphagen kinase C-terminal domain. {ECO:0000255|PROSITE-ProRule:PRU00843}.
SimilarityContains 1 phosphagen kinase N-terminal domain. {ECO:0000255|PROSITE-ProRule:PRU00842}.
Subcellular LocationMitochondrion inner membrane; Peripheral membrane protein; Intermembrane side.
SubunitExists as an octamer composed of four CKMT2 homodimers. {ECO:0000269|Ref.5}.
Tissue SpecificitySarcomere-specific. Found only in heart and skeletal muscles.
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