MGP Database

MGP000588

Record overview

MGPD IDMGP000588
Gene ID1191
SpeciesHomo sapiens (Human)
Gene Nameclusterin
Gene Symbol CLU
SynonymsCLI; AAG4; APOJ; CLU1; CLU2; KUB1; SGP2; APO-J; SGP-2; SP-40; TRPM2; TRPM-2; NA1/NA2;
Alternate namesclusterin; aging-associated protein 4; apolipoprotein J; complement cytolysis inhibitor; complement lysis inhibitor; complement-associated protein SP-40,40; ku70-binding protein 1; sulfated glycoprotein 2; testosterone-repressed prostate message 2;
Chromosome8
Map Location8p21-p12
SummaryThe protein encoded by this gene is a secreted chaperone that can under some stress conditions also be found in the cell cytosol. It has been suggested to be involved in several basic biological events such as cell death, tumor progression, and neurodegenerative disorders. Alternate splicing results in both coding and non-coding variants.[provided by RefSeq, May 2011]
OrthologsView orthologs and multiple alignments for CLU

Proteins

clusterin preproprotein
Refseq ID:NP_001822
Protein GI:355594753
UniProt ID:P10909
mRNA ID:NM_001831
Length:449
RefSeq Status:
MMKTLLLFVGLLLTWESGQVLGDQTVSDNELQEMSNQGSKYVNKEIQNAVNGVKQIKTLIEKTNEERKTLLSNLEEAKKKKEDALNETRESETKLKELPG
VCNETMMALWEECKPCLKQTCMKFYARVCRSGSGLVGRQLEEFLNQSSPFYFWMNGDRIDSLLENDRQQTHMLDVMQDHFSRASSIIDELFQDRFFTREP
QDTYHYLPFSLPHRRPHFFFPKSRIVRSLMPFSPYEPLNFHAMFQPFLEMIHEAQQAMDIHFHSPAFQHPPTEFIREGDDDRTVCREIRHNSTGCLRMKD
QCDKCREILSVDCSTNNPSQAKLRRELDESLQVAERLTRKYNELLKSYQWKMLNTSSLLEQLNEQFNWVSRLANLTQGEDQYYLRVTTVASHTSDSDVPS
GVTEVVVKLFDSDPITVTVPVEVSRKNPKFMETVAEKALQEYRKKHREE
 
sig_peptide: 1..22
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2450
peptide sequence: 
MMKTLLLFVGLLLTWESGQVLG

mat_peptide: 23..449
product: Clusterin
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P10909.1)
calculated_mol_wt: 50063
peptide sequence: 
DQTVSDNELQEMSNQGSKYVNKEIQNAVNGVKQIKTLIEKTNEERKTLLSNLEEAKKKKEDALNETRESETKLKELPGVCNETMMALWEECKPCLKQTCM
KFYARVCRSGSGLVGRQLEEFLNQSSPFYFWMNGDRIDSLLENDRQQTHMLDVMQDHFSRASSIIDELFQDRFFTREPQDTYHYLPFSLPHRRPHFFFPK
SRIVRSLMPFSPYEPLNFHAMFQPFLEMIHEAQQAMDIHFHSPAFQHPPTEFIREGDDDRTVCREIRHNSTGCLRMKDQCDKCREILSVDCSTNNPSQAK
LRRELDESLQVAERLTRKYNELLKSYQWKMLNTSSLLEQLNEQFNWVSRLANLTQGEDQYYLRVTTVASHTSDSDVPSGVTEVVVKLFDSDPITVTVPVE
VSRKNPKFMETVAEKALQEYRKKHREE mat_peptide: 23..227 product: Clusterin beta chain experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P10909.1) calculated_mol_wt: 24198 peptide sequence: DQTVSDNELQEMSNQGSKYVNKEIQNAVNGVKQIKTLIEKTNEERKTLLSNLEEAKKKKEDALNETRESETKLKELPGVCNETMMALWEECKPCLKQTCM
KFYARVCRSGSGLVGRQLEEFLNQSSPFYFWMNGDRIDSLLENDRQQTHMLDVMQDHFSRASSIIDELFQDRFFTREPQDTYHYLPFSLPHRRPHFFFPK
SRIVR mat_peptide: 228..449 product: Clusterin alpha chain experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P10909.1) calculated_mol_wt: 25883 peptide sequence: SLMPFSPYEPLNFHAMFQPFLEMIHEAQQAMDIHFHSPAFQHPPTEFIREGDDDRTVCREIRHNSTGCLRMKDQCDKCREILSVDCSTNNPSQAKLRREL
DESLQVAERLTRKYNELLKSYQWKMLNTSSLLEQLNEQFNWVSRLANLTQGEDQYYLRVTTVASHTSDSDVPSGVTEVVVKLFDSDPITVTVPVEVSRKN
PKFMETVAEKALQEYRKKHREE
 
  logo