MGP Database

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MGP000588

Ontology/Pathway Information

Entrez Gene ID1191
Gene Nameclusterin
Gene Symbol CLU
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0097440 IDA:Alzheimers_University_of_TorontoCapical dendrite
GO:0072562 IDA:UniProtKBCblood microparticle
GO:0042583 IEA:UniProtKB-SubCellCchromaffin granule
GO:0005737 IDA:Alzheimers_University_of_TorontoCcytoplasm
GO:0005829 IEA:UniProtKB-SubCellCcytosol
GO:0005783 IEA:UniProtKB-SubCellCendoplasmic reticulum
GO:0031012 IDA:UniProtKBCextracellular matrix
GO:0005576 TAS:ReactomeCextracellular region
GO:0005615 IDA:UniProtKBCextracellular space
GO:0070062 IDA:UniProtKBCextracellular vesicular exosome
GO:0031966 IEA:UniProtKB-SubCellCmitochondrial membrane
GO:0005739 IDA:BHF-UCLCmitochondrion
GO:0097418 IDA:Alzheimers_University_of_TorontoCneurofibrillary tangle
GO:0005634 IEA:UniProtKB-SubCellCnucleus
GO:0048471 IDA:UniProtKBCperinuclear region of cytoplasm
GO:0031093 TAS:ReactomeCplatelet alpha granule lumen
GO:0034366 IDA:BHF-UCLCspherical high-density lipoprotein particle
GO:0051787 IDA:UniProtKBFmisfolded protein binding
GO:0031625 IDA:UniProtKBFubiquitin protein ligase binding
GO:0007596 TAS:ReactomePblood coagulation
GO:0000902 IDA:Alzheimers_University_of_TorontoPcell morphogenesis
GO:0032286 IMP:Alzheimers_University_of_TorontoPcentral nervous system myelin maintenance
GO:0051131 IDA:Alzheimers_University_of_TorontoPchaperone-mediated protein complex assembly
GO:0061077 IDA:UniProtKBPchaperone-mediated protein folding
GO:0006956 TAS:ProtIncPcomplement activation
GO:0006958 IEA:UniProtKB-KWPcomplement activation, classical pathway
GO:0045087 IEA:UniProtKB-KWPinnate immune response
GO:0097193 IDA:UniProtKBPintrinsic apoptotic signaling pathway
GO:0006629 NAS:ProtIncPlipid metabolic process
GO:0001774 IDA:Alzheimers_University_of_TorontoPmicroglial cell activation
GO:0061518 IDA:Alzheimers_University_of_TorontoPmicroglial cell proliferation
GO:1902430 IDA:Alzheimers_University_of_TorontoPnegative regulation of beta-amyloid formation
GO:1902230 IMP:BHF-UCLPnegative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO:0032463 IMP:BHF-UCLPnegative regulation of protein homooligomerization
GO:0030168 TAS:ReactomePplatelet activation
GO:0002576 TAS:ReactomePplatelet degranulation
GO:0043065 IMP:UniProtKBPpositive regulation of apoptotic process
GO:1902004 ISS:Alzheimers_University_of_TorontoPpositive regulation of beta-amyloid formation
GO:2001244 IMP:UniProtKBPpositive regulation of intrinsic apoptotic signaling pathway
GO:1902998 IMP:Alzheimers_University_of_TorontoPpositive regulation of neurofibrillary tangle assembly
GO:1901216 IDA:Alzheimers_University_of_TorontoPpositive regulation of neuron death
GO:0051092 IMP:UniProtKBPpositive regulation of NF-kappaB transcription factor activity
GO:0045429 IDA:Alzheimers_University_of_TorontoPpositive regulation of nitric oxide biosynthetic process
GO:0032436 IMP:UniProtKBPpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:2000060 IMP:UniProtKBPpositive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:1902949 IMP:Alzheimers_University_of_TorontoPpositive regulation of tau-protein kinase activity
GO:0032760 IDA:Alzheimers_University_of_TorontoPpositive regulation of tumor necrosis factor production
GO:0017038 IDA:Alzheimers_University_of_TorontoPprotein import
GO:0050821 IDA:UniProtKBPprotein stabilization
GO:1900221 IDA:Alzheimers_University_of_TorontoPregulation of beta-amyloid clearance
GO:1902847 IMP:Alzheimers_University_of_TorontoPregulation of neuronal signal transduction
GO:1901214 IDA:Alzheimers_University_of_TorontoPregulation of neuron death
GO:0001836 IC:BHF-UCLPrelease of cytochrome c from mitochondria
GO:0051788 IDA:BHF-UCLPresponse to misfolded protein
GO:0009615 IEP:UniProtKBPresponse to virus
GO:0043691 TAS:BHF-UCLPreverse cholesterol transport
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_604Hemostasis
REACT_798Platelet activation, signaling and aggregation
REACT_318Platelet degranulation
REACT_1280Response to elevated platelet cytosolic Ca2+
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