MGP Database

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MGP000595

UniProt Annotations

Entry Information
Gene Nameclathrin, heavy chain (Hc)
Protein Entry
UniProt ID
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q00610-1; Sequence=Displayed; Name=2; IsoId=Q00610-2; Sequence=VSP_011570, VSP_011571; Note=No experimental confirmation available.;
DomainThe N-terminal seven-bladed beta-propeller is formed by WD40-like repeats, and projects inward from the polyhedral outer clathrin coat. It consitutes a major protein-protein interaction node.
FunctionClathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network.
InteractionP10242:MYB; NbExp=4; IntAct=EBI-354967, EBI-298355; Q01968:OCRL; NbExp=4; IntAct=EBI-354967, EBI-6148898; O75674:TOM1L1; NbExp=4; IntAct=EBI-354967, EBI-712991;
Sequence CautionSequence=BAA04801.2; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the clathrin heavy chain family. {ECO:0000305}.
SimilarityContains 7 CHCR (clathrin heavy-chain) repeats. {ECO:0000255|PROSITE-ProRule:PRU01006}.
Subcellular LocationCytoplasmic vesicle membrane {ECO:0000269|PubMed:17081065}; Peripheral membrane protein {ECO:0000269|PubMed:17081065}; Cytoplasmic side {ECO:0000269|PubMed:17081065}. Membrane, coated pit {ECO:0000269|PubMed:17081065}; Peripheral membrane protein {ECO:0000269|PubMed:17081065}; Cytoplasmic side {ECO:0000269|PubMed:17081065}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Cytoplasmic face of coated pits and vesicles. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
SubunitClathrin triskelions, composed of 3 heavy chains and 3 light chains, are the basic subunits of the clathrin coat. In the presence of light chains, hub assembly is influenced by both the pH and the concentration of calcium. Interacts with HIP1. Interacts with DENND1A, DENND1B and DENND1C (By similarity). May interact with OCRL. Interacts with ERBB2 (By similarity). Interacts with FKBP6. {ECO:0000250, ECO:0000269|PubMed:11532990, ECO:0000269|PubMed:16314522, ECO:0000269|PubMed:18529014, ECO:0000269|PubMed:21816279}.
Web ResourceName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/CLTCID360.html";
Web ResourceName=Wikipedia; Note=Clathrin entry; URL="http://en.wikipedia.org/wiki/Clathrin";
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