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MGP000596

Record overview

MGPD IDMGP000596
Gene ID1215
SpeciesHomo sapiens (Human)
Gene Namechymase 1, mast cell
Gene Symbol CMA1
SynonymsCYH; MCT1; chymase;
Alternate nameschymase; alpha-chymase; chymase, heart; chymase, mast cell; mast cell protease I; chymase 1 preproprotein transcript E; chymase 1 preproprotein transcript I;
Chromosome14
Map Location14q11.2
EC Number3.4.21.39
SummaryThis gene product is a chymotryptic serine proteinase that belongs to the peptidase family S1. It is expressed in mast cells and thought to function in the degradation of the extracellular matrix, the regulation of submucosal gland secretion, and the generation of vasoactive peptides. In the heart and blood vessels, this protein, rather than angiotensin converting enzyme, is largely responsible for converting angiotensin I to the vasoactive peptide angiotensin II. Angiotensin II has been implicated in blood pressure control and in the pathogenesis of hypertension, cardiac hypertrophy, and heart failure. Thus, this gene product is a target for cardiovascular disease therapies. This gene maps to 14q11.2 in a cluster of genes encoding other proteases. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for CMA1

Proteins

chymase preproprotein
Refseq ID:NP_001827
Protein GI:4502907
UniProt ID:P23946
mRNA ID:NM_001836
Length:247
RefSeq Status:
MLLLPLPLLLFLLCSRAEAGEIIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRNFVLTAAHCAGRSITVTLGAHNITEEEDTWQKLEVIKQFRHP
KYNTSTLHHDIMLLKLKEKASLTLAVGTLPFPSQFNFVPPGRMCRVAGWGRTGVLKPGSDTLQEVKLRLMDPQACSHFRDFDHNLQLCVGNPRKTKSAFK
GDSGGPLLCAGVAQGIVSYGRSDAKPPAVFTRISHYRPWINQILQAN
 
sig_peptide: 1..19
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2127
peptide sequence: 
MLLLPLPLLLFLLCSRAEA

mat_peptide: 22..247
product: chymase
calculated_mol_wt: 25030
peptide sequence: 
IIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRNFVLTAAHCAGRSITVTLGAHNITEEEDTWQKLEVIKQFRHPKYNTSTLHHDIMLLKLKEKAS
LTLAVGTLPFPSQFNFVPPGRMCRVAGWGRTGVLKPGSDTLQEVKLRLMDPQACSHFRDFDHNLQLCVGNPRKTKSAFKGDSGGPLLCAGVAQGIVSYGR
SDAKPPAVFTRISHYRPWINQILQAN
 
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