MGP Database

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MGP000596

UniProt Annotations

Entry Information
Gene Namechymase 1, mast cell
Protein EntryCMA1_HUMAN
UniProt IDP23946
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P23946-1; Sequence=Displayed; Name=2; IsoId=P23946-2; Sequence=VSP_056947; Note=No experimental confirmation available.;
Catalytic ActivityPreferential cleavage: Phe-|-Xaa > Tyr-|-Xaa > Trp-|-Xaa > Leu-|-Xaa.
FunctionMajor secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion.
SimilarityBelongs to the peptidase S1 family. Granzyme subfamily. {ECO:0000255|PROSITE-ProRule:PRU00274}.
SimilarityContains 1 peptidase S1 domain. {ECO:0000255|PROSITE- ProRule:PRU00274}.
Subcellular LocationSecreted. Cytoplasmic granule. Note=Mast cell granules.
Tissue SpecificityMast cells in lung, heart, skin and placenta. Expressed in both normal skin and in urticaria pigmentosa lesions. {ECO:0000269|PubMed:8144971}.
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