MGP Database

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MGP000668

UniProt Annotations

Entry Information
Gene Nameclaudin 7
Protein EntryCLD7_HUMAN
UniProt IDO95471
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=O95471-1; Sequence=Displayed; Name=2; Synonyms=t-CLDN-7; IsoId=O95471-2; Sequence=VSP_013230;
FunctionPlays a major role in tight junction-specific obliteration of the intercellular space. {ECO:0000250}.
InductionBy androgens. {ECO:0000269|PubMed:14502431}.
InteractionP09758:TACSTD2; NbExp=2; IntAct=EBI-740744, EBI-4324738;
PtmPhosphorylated. {ECO:0000269|PubMed:16054130}.
Sequence CautionSequence=AAP97219.1; Type=Frameshift; Positions=18, 23; Evidence={ECO:0000305};
SimilarityBelongs to the claudin family. {ECO:0000305}.
Subcellular LocationCell membrane; Multi-pass membrane protein. Lateral cell membrane. Cell junction, tight junction. Note=Co- localizes with EPCAM at the lateral cell membrane and tight junction.
SubunitDirectly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO- 3 (By similarity). The phosphorylated form interacts with EPCAM. {ECO:0000250, ECO:0000269|PubMed:16054130}.
Tissue SpecificityExpressed in kidney, lung and prostate. Isoform 1 seems to be predominant, except in some normal prostate samples, where isoform 2 is the major form. Down-regulated in breast cancers, including ductal carcinoma in situ (DCIS), lobular carcinoma in situ (LCIS) and invasive ductal carcinoma (IDC) (at protein level), as well as in several cancer cell lines. Loss of expression correlates with histological grade, occurring predominantly in high-grade lesions. {ECO:0000269|PubMed:12673207, ECO:0000269|PubMed:14502431}.
Web ResourceName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/CLDN7ID40099ch17p13.html";
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