MGP Database

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MGP000677

UniProt Annotations

Entry Information
Gene Namecellular retinoic acid binding protein 2
Protein EntryRABP2_HUMAN
UniProt IDP29373
SpeciesHuman
Comments
Comment typeDescription
DomainForms a beta-barrel structure that accommodates hydrophobic ligands in its interior.
FunctionTransports retinoic acid to the nucleus. Regulates the access of retinoic acid to the nuclear retinoic acid receptors.
InductionBy retinoic acid.
PtmSumoylated in response to retinoic acid binding, sumoylation is critical for dissociation from ER and subsequent nuclear translocation. {ECO:0000269|PubMed:21998312}.
SimilarityBelongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. {ECO:0000305}.
Subcellular LocationCytoplasm. Endoplasmic reticulum. Nucleus. Note=Upon ligand binding, a conformation change exposes a nuclear localization motif and the protein is transported into the nucleus.
SubunitInteracts with RXR and RARA (By similarity). Interacts with importin alpha. {ECO:0000250, ECO:0000269|PubMed:11909957, ECO:0000269|PubMed:17447762}.
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