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MGP000685

Record overview

MGPD IDMGP000685
Gene ID1398
SpeciesHomo sapiens (Human)
Gene Namev-crk avian sarcoma virus CT10 oncogene homolog
Gene Symbol CRK
Synonymsp38; CRKII;
Alternate namesadapter molecule crk; proto-oncogene c-Crk;
Chromosome17
Map Location17p13.3
SummaryThis gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for CRK

Proteins

adapter molecule crk isoform a
Refseq ID:NP_058431
Protein GI:41327712
UniProt ID:P46108
mRNA ID:NM_016823
Length:304
RefSeq Status:
MAGNFDSEERSSWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHYIINSSGPRPPVPPSPAQPPPGVSPSRLRIGDQEFDSLPAL
LEFYKIHYLDTTTLIEPVSRSRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRGMIPVPYVEKYRPASASVSAL
IGGNQEGSHPQPLGGPEPGPYAQPSVNTPLPNLQNGPIYARVIQKRVPNAYDKTALALEVGELVKVTKINVSGQWEGECNGKRGHFPFTHVRLLDQQNPD
EDFS
 
adapter molecule crk isoform b
Refseq ID:NP_005197
Protein GI:41327710
UniProt ID:P46108
mRNA ID:NM_005206
Length:204
RefSeq Status:
MAGNFDSEERSSWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHYIINSSGPRPPVPPSPAQPPPGVSPSRLRIGDQEFDSLPAL
LEFYKIHYLDTTTLIEPVSRSRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRGMIPVPYVEKYRPASASVSAL
IGGR
 
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