MGP Database

MGP000698

Ontology/Pathway Information

Entrez Gene ID	1445
Gene Name	c-src tyrosine kinase
Gene Symbol	CSK
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005911	IEA:Ensembl	C	cell-cell junction
GO:0005737	TAS:HGNC	C	cytoplasm
GO:0005829	TAS:Reactome	C	cytosol
GO:0070062	IDA:UniProtKB	C	extracellular vesicular exosome
GO:0045121	IEA:Ensembl	C	membrane raft
GO:0005886	IPI:UniProtKB	C	plasma membrane
GO:0005524	IEA:UniProtKB-KW	F	ATP binding
GO:0042802	IPI:IntAct	F	identical protein binding
GO:0004715	IEA:UniProtKB-EC	F	non-membrane spanning protein tyrosine kinase activity
GO:0008022	TAS:ProtInc	F	protein C-terminus binding
GO:0004713	TAS:Reactome	F	protein tyrosine kinase activity
GO:0034332	IEA:Ensembl	P	adherens junction organization
GO:0007596	TAS:Reactome	P	blood coagulation
GO:0007420	IEA:Ensembl	P	brain development
GO:0071375	IEA:Ensembl	P	cellular response to peptide hormone stimulus
GO:0007173	TAS:Reactome	P	epidermal growth factor receptor signaling pathway
GO:0045779	IEA:Ensembl	P	negative regulation of bone resorption
GO:0008285	IEA:Ensembl	P	negative regulation of cell proliferation
GO:0070373	IEA:Ensembl	P	negative regulation of ERK1 and ERK2 cascade
GO:0042997	IDA:UniProtKB	P	negative regulation of Golgi to plasma membrane protein transport
GO:0032715	IEA:Ensembl	P	negative regulation of interleukin-6 production
GO:0033673	IEA:Ensembl	P	negative regulation of kinase activity
GO:0010989	IEA:Ensembl	P	negative regulation of low-density lipoprotein particle clearance
GO:0050765	IEA:Ensembl	P	negative regulation of phagocytosis
GO:0048709	IEA:Ensembl	P	oligodendrocyte differentiation
GO:0018108	TAS:GOC	P	peptidyl-tyrosine phosphorylation
GO:0030168	TAS:Reactome	P	platelet activation
GO:0043406	IEA:Ensembl	P	positive regulation of MAP kinase activity
GO:0046777	IEA:Ensembl	P	protein autophosphorylation
GO:0006468	TAS:ProtInc	P	protein phosphorylation
GO:0060368	IEA:Ensembl	P	regulation of Fc receptor mediated stimulatory signaling pathway
GO:0031295	TAS:Reactome	P	T cell costimulation
GO:0050852	TAS:Reactome	P	T cell receptor signaling pathway

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_75774	Adaptive Immune System
REACT_19344	Costimulation by the CD28 family
REACT_116125	Disease
REACT_12578	GAB1 signalosome
REACT_604	Hemostasis
REACT_6900	Immune System
REACT_15523	Integrin alphaIIb beta3 signaling
REACT_19324	PD-1 signaling
REACT_12582	Phosphorylation of CD3 and TCR zeta chains
REACT_798	Platelet activation, signaling and aggregation
REACT_278	Platelet Aggregation (Plug Formation)
REACT_9417	Signaling by EGFR
REACT_115871	Signaling by EGFR in Cancer
REACT_268269	Signaling by EGFRvIII in Cancer
REACT_268006	Signaling by Ligand-Responsive EGFR Variants in Cancer
REACT_268546	Signaling by Overexpressed Wild-Type EGFR in Cancer
REACT_111102	Signal Transduction
REACT_12526	TCR signaling